Structure of PDB 3s9s Chain A

Receptor sequence
>3s9sA (length=258) Species: 9606 (Homo sapiens) [Search protein sequence]
SADLRALAKHLYDSYIKSFPLTKAKARAILTGKSPFVIYDMNSLMMGEDK
IKFKHITKEVAIRIFQGCQFRSVEAVQEITEYAKSIPGFVNLDLNDQVTL
LKYGVHEIIYTMLASLMNKDGVLISEGQGFMTREFLKSLRKPFGDFMEPK
FEFAVKFNALELDDSDLAIFIAVIILSGDRPGLLNVKPIEDIQDNLLQAL
ELQLKLNHPESSQLFAKLLQKMTDLRQIVTEHVQLLQVIKKTETMSLHPL
LQEIYKDL
3D structure
PDB3s9s Discovery of GSK1997132B a novel centrally penetrant benzimidazole PPARgamma partial agonist.
ChainA
Resolution2.55 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 peptide A T297 V315 L318 K319 E471 T80 V98 L101 K102 E253
BS02 M0T A F282 C285 Q286 R288 S289 H323 Y327 L330 I341 F363 M364 H449 Y473 F65 C68 Q69 R71 S72 H106 Y110 L113 I124 F146 M147 H232 Y255
Gene Ontology
Molecular Function
GO:0003677 DNA binding
GO:0004879 nuclear receptor activity
Biological Process
GO:0006355 regulation of DNA-templated transcription
Cellular Component
GO:0005634 nucleus

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:3s9s, PDBe:3s9s, PDBj:3s9s
PDBsum3s9s
PubMed21798739
UniProtP37231|PPARG_HUMAN Peroxisome proliferator-activated receptor gamma (Gene Name=PPARG)

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