Structure of PDB 3s8h Chain A

Receptor sequence
>3s8hA (length=292) Species: 287 (Pseudomonas aeruginosa) [Search protein sequence]
MIAGSMVALVTPFDAQGRLDWDSLAKLVDFHLQDGTNAIVAVGTTGESAT
LDVEEHIQVVRRVVDQVKGRIPVIAGTGANSTREAVALTEAAKSGGADAC
LLVTPYYNKPTQEGMYQHFRHIAEAVAIPQILYNVPGRTSCDMLPETVER
LSKVPNIIGIKEATGDLQRAKEVIERVGKDFLVYSGDDATAVELMLLGGK
GNISVTANVAPRAMSDLCAAAMRGDAAAARAINDRLMPLHKALFIESNPI
PVKWALHEMGLIPEGIRLPLTWLSPHCHDPLRQAMRQTGVLA
3D structure
PDB3s8h Structure of dihydrodipicolinate synthase complexed with 3-Hydroxypropanoic acid(HPA)at 2.70 A resolution
ChainA
Resolution2.7 Å
3D
structure
Catalytic site residues are labeled in the structure
[Spin on]
[Spin off]
[Reset orientation]

[High quality]
[Low quality]

[White background]
[Black background]

[Download]
[Download structure with residue number starting from 1]
Enzymatic activity
Catalytic site (original residue number in PDB) T44 Y107 Y133 R138 K161 I203
Catalytic site (residue number reindexed from 1) T44 Y107 Y133 R138 K161 I203
Enzyme Commision number 4.3.3.7: 4-hydroxy-tetrahydrodipicolinate synthase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 3OH A A8 L9 V40 G43 T44 T45 G46 K161 A8 L9 V40 G43 T44 T45 G46 K161
Gene Ontology
Molecular Function
GO:0008840 4-hydroxy-tetrahydrodipicolinate synthase activity
GO:0016829 lyase activity
Biological Process
GO:0009085 lysine biosynthetic process
GO:0009089 lysine biosynthetic process via diaminopimelate
GO:0019877 diaminopimelate biosynthetic process
GO:0044281 small molecule metabolic process
Cellular Component
GO:0005737 cytoplasm
GO:0005829 cytosol

View graph for
Molecular Function
View graph for
Biological Process
View graph for
Cellular Component
External links
PDB RCSB:3s8h, PDBe:3s8h, PDBj:3s8h
PDBsum3s8h
PubMed
UniProtQ9I4W3|DAPA_PSEAE 4-hydroxy-tetrahydrodipicolinate synthase (Gene Name=dapA)

[Back to BioLiP]