Structure of PDB 3s8c Chain A

Receptor sequence
>3s8cA (length=666) Species: 559292 (Saccharomyces cerevisiae S288C) [Search protein sequence]
YATLAARIAISNLHKQTTKQFSKVVEDLYRYVNAATGKPAPMISDDVYNI
VMENKDKLNSAIVYDRDFQYSYFGFKTLERSYLLRINGQVAERPQHLIMR
VALGIHGRDIEAALETYNLMSLKYFTHASPTLFNAGTPKPQMSSCFLVAM
KEDSIEGIYDTLKECALISKTAGGIGLHIHNIRSTGSYIAGTNGTSNGLI
PMIRVFNNTARYVDQGGNKAPGAFALYLEPWHADIFDFIDIRKNHGKEEI
RARDLFPALWIPDLFMKRVEENGTWTLFSPTSAPGLSDCYGDEFEALYTR
YEKEGRGKTIKAQKLWYSILEAQTETGTPFVVYKDACNRKSNQKNLGVIK
SSNLCCEIVEYSAPDETAVCNLASVALPAFIETSEDGKTSTYNFKKLHEI
AKVVTRNLNRVIDRNYYPVEEARKSNMRHRPIALGVQGLADTFMLLRLPF
DSEEARLLNIQIFETIYHASMEASCELAQKDGPYETFQGSPASQGILQFD
MWDQKPYGMWDWDTLRKDIMKHGVRNSLTMAPMPTASTSQILGYNECFEP
VTSNMYSFQVVNPYLLRDLVDLGIWDEGMKQYLITQNGSIQGLPNVPQEL
KDLYKTVWEISQKTIINMAADRSVYIDQSHSLNLFLRAPTMGKLTSMHFY
GWKKGLKTGMYYLRTQ
3D structure
PDB3s8c Structural and biochemical basis of lethal mutant R293A of yeast ribonucleotide reductase
ChainA
Resolution2.77 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) C218 N426 C428 E430 C443 Y741 Y742
Catalytic site (residue number reindexed from 1) C145 N353 C355 E357 C370 Y661 Y662
Enzyme Commision number 1.17.4.1: ribonucleoside-diphosphate reductase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ANP A D226 S227 I228 R256 I262 A263 D153 S154 I155 R183 I189 A190
BS02 CDP A A201 S202 S217 G246 G247 K292 P607 T608 A609 S610 T611 A128 S129 S144 G173 G174 K219 P534 T535 A536 S537 T538
Gene Ontology
Molecular Function
GO:0000166 nucleotide binding
GO:0004748 ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0016491 oxidoreductase activity
GO:0042802 identical protein binding
Biological Process
GO:0009263 deoxyribonucleotide biosynthetic process
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005971 ribonucleoside-diphosphate reductase complex

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:3s8c, PDBe:3s8c, PDBj:3s8c
PDBsum3s8c
PubMed
UniProtP21524|RIR1_YEAST Ribonucleoside-diphosphate reductase large chain 1 (Gene Name=RNR1)

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