Structure of PDB 3s5f Chain A

Receptor sequence
>3s5fA (length=120) Species: 9606 (Homo sapiens) [Search protein sequence]
SLDETTYERLAEETLDSLAEFFEDLADKPYTFEDYDVSFGSGVLTVKLGG
DLGTYVINKQTPNKQIFLSSPSSGPKRYDWTGKNWVYSHDGVSLHELLAA
ELTKALKTKLDLSSLAYSGK
3D structure
PDB3s5f Friedreich's Ataxia Variants I154F and W155R Diminish Frataxin-Based Activation of the Iron-Sulfur Cluster Assembly Complex.
ChainA
Resolution1.5 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 1.16.3.1: ferroxidase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 MG A A114 K116 T119 A26 K28 T31
Gene Ontology
Molecular Function
GO:0004322 ferroxidase activity
GO:0008199 ferric iron binding
Biological Process
GO:0006879 intracellular iron ion homeostasis
GO:0016226 iron-sulfur cluster assembly
GO:0018283 iron incorporation into metallo-sulfur cluster
Cellular Component
GO:0005739 mitochondrion

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Biological Process
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Cellular Component
External links
PDB RCSB:3s5f, PDBe:3s5f, PDBj:3s5f
PDBsum3s5f
PubMed21671584
UniProtQ16595|FRDA_HUMAN Frataxin, mitochondrial (Gene Name=FXN)

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