Structure of PDB 3s5a Chain A

Receptor sequence
>3s5aA (length=204) Species: 9606 (Homo sapiens) [Search protein sequence]
MSWRHIRAEGLDSSYTVLFGKAEADEIFQELEKEVEYFTGALARVQVFGK
WHSVPRKQATYGDAGLTYTFSGLTLSPKPWIPVLERIRDHVSGVTGQTFN
FVLINRYKDGSDHICEHRDDERELAPGSPIASVSFGASRDFVFRHKDSRG
KSPSRRVAVVRLPLAHGSLLMMNHPTNTHWYHSLPVRKKVLAPRVNLTFR
KILL
3D structure
PDB3s5a Duplex interrogation by a direct DNA repair protein in search of base damage
ChainA
Resolution1.7 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 1.14.11.33: DNA oxidative demethylase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 dna A V101 F102 H106 P109 R110 H167 C169 R172 Y235 V47 F48 H52 P55 R56 H113 C115 R118 Y181
BS02 dna A F102 K205 K242 F48 K151 K188
BS03 MN A H171 D173 H236 H117 D119 H182
BS04 AKG A Y161 I168 H171 H236 R248 N250 Y107 I114 H117 H182 R194 N196
Gene Ontology

View graph for
Biological Process
External links
PDB RCSB:3s5a, PDBe:3s5a, PDBj:3s5a
PDBsum3s5a
PubMed22659876
UniProtQ6NS38|ALKB2_HUMAN DNA oxidative demethylase ALKBH2 (Gene Name=ALKBH2)

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