Structure of PDB 3s45 Chain A

Receptor sequence
>3s45A (length=99) Species: 11709 (Human immunodeficiency virus 2) [Search protein sequence]
PQFSLWKRPVVTAYIEGQPVEVLLDTGADDSIVAGIELGNNYSPKIVGGI
GGFINTKEYKNVEIEVLNKKVRATIMTGDTPINIFGRNILTALGMSLNL
3D structure
PDB3s45 Critical differences in HIV-1 and HIV-2 protease specificity for clinical inhibitors.
ChainA
Resolution1.51 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) D25 T26 G27
Catalytic site (residue number reindexed from 1) D25 T26 G27
Enzyme Commision number 3.4.23.47: HIV-2 retropepsin.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 478 A D25 A28 D30 I32 I82 I84 D25 A28 D30 I32 I82 I84 PDBbind-CN: -logKd/Ki=8.49,Ki=3.24nM
Gene Ontology
Molecular Function
GO:0004190 aspartic-type endopeptidase activity
GO:0046872 metal ion binding
Biological Process
GO:0006508 proteolysis

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Molecular Function
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Biological Process
External links
PDB RCSB:3s45, PDBe:3s45, PDBj:3s45
PDBsum3s45
PubMed22238126
UniProtQ9W9R3

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