Structure of PDB 3s04 Chain A

Receptor sequence
>3s04A (length=209) Species: 83333 (Escherichia coli K-12) [Search protein sequence]
FIYEPFQIPSGSMMPTLLIGDFILVEKFAHPKRGDIVVFKYPEDPKLDYI
KRAVGLPGDKVTYDPVSKELTIQPGCSACENALPVTYSNVEPSDFVQTFT
SGFFEVPKNETKENGIRLSERKETLGDVTHRILTVPIAQDQVGMYYQQPG
QQLATWIVPPGQYFMMGDNRDNSADSRYWGFVPEANLVGRATAIWMSFDL
RLSRIGGIH
3D structure
PDB3s04 Synthesis and characterization of the arylomycin lipoglycopeptide antibiotics and the crystallographic analysis of their complex with signal peptidase.
ChainA
Resolution2.44 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) S89 S91 K146 S279
Catalytic site (residue number reindexed from 1) S10 S12 K51 S173
Enzyme Commision number 3.4.21.89: signal peptidase I.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 peptide A F85 Q86 P88 D143 Y144 I145 K146 F6 Q7 P9 D48 Y49 I50 K51
Gene Ontology
Molecular Function
GO:0004252 serine-type endopeptidase activity
GO:0008236 serine-type peptidase activity
Biological Process
GO:0006465 signal peptide processing
GO:0006508 proteolysis
Cellular Component
GO:0016020 membrane

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Cellular Component
External links
PDB RCSB:3s04, PDBe:3s04, PDBj:3s04
PDBsum3s04
PubMed21999324
UniProtP00803|LEP_ECOLI Signal peptidase I (Gene Name=lepB)

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