Structure of PDB 3rzj Chain A

Receptor sequence

>3rzjA (length=203) Species: 9606 (Homo sapiens) [Search protein sequence]

GSHSWRHIRAEGLDSSYTVLFGKAEADEIFQELEKEVEYFTGALARVQVF
GKWHSVPRKQATYGDAGLTYTFSGLTLSPKPWIPVLERIRDHVSGVTGQT
FNFVLINRYKDGSDHICEHRDDERELAPGSPIASVSFGASRDFVFRHKDS
RPSRRVAVVRLPLAHGSLLMMNHPTNTHWYHSLPVRKKVLAPRVNLTFRK
ILL

3D structure

PDB

3rzj Duplex interrogation by a direct DNA repair protein in search of base damage

Chain

Resolution

2.5 Å

3D
structure

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Enzymatic activity

Enzyme Commision number

1.14.11.33: DNA oxidative demethylase.

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)
BS01	dna	A	V101 F102 H106 R110 F124 S125 H167 I168 C169 H171 R172 D173 E175 Y235	V49 F50 H54 R58 F72 S73 H115 I116 C117 H119 R120 D121 E123 Y180
BS02	dna	A	F102 G103 R241 K242	F50 G51 R186 K187
BS03	MN	A	H171 D173 H236	H119 D121 H181
BS04	AKG	A	Y161 H171 H236 R248 N250 T252 R254	Y109 H119 H181 R193 N195 T197 R199

Gene Ontology

	Biological Process
GO:0006281	DNA repair

View graph for
Biological Process

External links

PDB	RCSB:3rzj, PDBe:3rzj, PDBj:3rzj
PDBsum	3rzj
PubMed	22659876
UniProt	Q6NS38\|ALKB2_HUMAN DNA oxidative demethylase ALKBH2 (Gene Name=ALKBH2)

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