Structure of PDB 3rvb Chain A

Receptor sequence
>3rvbA (length=443) [Search protein sequence]
DNSSPPAVPQTFQVAHLHAPTGSGKSTKVPAAYAAQGYKVLVLNPSVAAT
LGFGVYMSKAHGIDPNIRTGVRAITTGGPITYSTYGKFLADGGCSAYDII
ICDECHSTDSTSILGIGTVLDQAETAGARLVVLATATPPGSVTVPHPNIE
EVALSNTGEIPFYGKAIPIEVIRGGRHLIFCHSKKKCDELAAKLSALGLN
AVAYYRGLDVSVIPTSGDVVVVATDALMTGYTGDFDSVIDCNTCVTQTVD
FSLDPTFTIDTTTVPQDAVSRSQRRGRTGRGRRGIYRFVTPGERPSGMFD
SSVLCECYDAGCAWYELTPAETSVRLRAYLNTPGLPVCQDHLEFWESVFT
GLTHIDAHFLSQTKQAGDNFPYLVAYQATVCARAQAPPPSWDQMWKSLTR
LKPTLHGPTPLLYRLGALQNEVTLTHPVTKFIMACMSADLEVV
3D structure
PDB3rvb The structure of HCV NS3 helicase with inhibitor ITMN-3479
ChainA
Resolution2.2 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.7.7.48: RNA-directed RNA polymerase.
3.4.21.98: hepacivirin.
3.4.22.-
3.6.1.15: nucleoside-triphosphate phosphatase.
3.6.4.13: RNA helicase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 I79 A G255 T269 G271 K272 A275 T298 A497 W501 Y502 G70 T84 G86 K87 A90 T111 A310 W314 Y315
BS02 MG A G209 S211 T212 G24 S26 T27
Gene Ontology
Molecular Function
GO:0004386 helicase activity
GO:0005524 ATP binding
GO:0008236 serine-type peptidase activity
Biological Process
GO:0006508 proteolysis
GO:0019087 transformation of host cell by virus

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Molecular Function
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Biological Process
External links
PDB RCSB:3rvb, PDBe:3rvb, PDBj:3rvb
PDBsum3rvb
PubMed
UniProtP26663|POLG_HCVBK Genome polyprotein

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