Structure of PDB 3ruu Chain A

Receptor sequence
>3ruuA (length=229) Species: 9606 (Homo sapiens) [Search protein sequence]
ELTPDQQTLLHFIMDSYNKQRMPQEITNKILKEEFSAEENFLILTEMATN
HVQVLVEFTKKLPGFQTLDHEDQIALLKGSAVEAMFLRSAEIFNKKLPSG
HSDLLEERIRNSGISDEYITPMFSFYKSIGELKMTQEEYALLTAIVILSP
DRQYIKDREAVEKLQEPLLDVLQKLCKIHQPENPQHFACLLGRLTELRTF
NHHHAEMLMSWRVNDHKFTPLLCEIWDVQ
3D structure
PDB3ruu Conformationally constrained farnesoid X receptor (FXR) agonists: Alternative replacements of the stilbene.
ChainA
Resolution2.502 Å
3D
structure
[Spin on]
[Spin off]
[Reset orientation]

[High quality]
[Low quality]

[White background]
[Black background]

[Download]
[Download structure with residue number starting from 1]
Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 peptide A K303 K321 P463 L464 E467 K60 K78 P220 L221 E224
BS02 37G A M265 T270 L287 T288 M290 A291 H294 M328 F329 R331 S342 Y369 H447 W454 M22 T27 L44 T45 M47 A48 H51 M85 F86 R88 S99 Y126 H204 W211 BindingDB: EC50=20nM
Gene Ontology
Molecular Function
GO:0003677 DNA binding
GO:0004879 nuclear receptor activity
GO:0032052 bile acid binding
Biological Process
GO:0006355 regulation of DNA-templated transcription
GO:0038183 bile acid signaling pathway

View graph for
Molecular Function
View graph for
Biological Process
External links
PDB RCSB:3ruu, PDBe:3ruu, PDBj:3ruu
PDBsum3ruu
PubMed21890356
UniProtQ96RI1|NR1H4_HUMAN Bile acid receptor (Gene Name=NR1H4)

[Back to BioLiP]