Structure of PDB 3rsr Chain A

Receptor sequence
>3rsrA (length=610) Species: 4932 (Saccharomyces cerevisiae) [Search protein sequence]
QTTKQFSKVVEDLYRYVNAATGKPAPMISDDVYNIVMENKDKLNSAIVYD
RDFQYSYFGFKTLERSYLLRINGQVAERPQHLIMRVALGIHGRDIEAALE
TYNLMSLKYFTHASPTLFNAGTPKPQMSSCFLVAMKEDSIEGIYDTLKEC
ALISKTAGGIGLHIHNIRSTGSYIAGTNGTSNGLIPMIRVFNNTARYVFA
LYLEPWHADIFDFIDIRKDLFPALWIPDLFMKRVEENGTWTLFSPTSAPG
LSDCYGDEFEALYTRYEKEGRGKTIKAQKLWYSILEAQTETGTPFVVYKD
ACNRKSNQKNLGVIKSSNLCCEIVEYSAPDETAVCNLASVALPAFIETSK
TSTYNFKKLHEIAKVVTRNLNRVIDRNYYPVEEARKSNMRHRPIALGVQG
LADTFMLLRLPFDSEEARLLNIQIFETIYHASMEASCELAQKDGPYETFQ
GSPASQGILQFDMWDQKPYGMWDWDTLRKDIMKHGVRNSLTMAPMPTTSQ
ILGYNECFEPNPYLLRDLVDLGIWQYLITQNGSIQGLPNVPQELKDLYKT
VWEISQKTIINMAADRSVYIDQSHSLNLFLRAPTMGKLTSMHFYGWKKGL
KTGMYYLRTQ
3D structure
PDB3rsr Evaluating the therapeutic potential of a non-natural nucleotide that inhibits human ribonucleotide reductase.
ChainA
Resolution2.3 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) C218 N406 C408 E410 C423 Y693 Y694
Catalytic site (residue number reindexed from 1) C130 N318 C320 E322 C335 Y605 Y606
Enzyme Commision number 1.17.4.1: ribonucleoside-diphosphate reductase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 N5P A D226 S227 I228 R256 I262 A263 G264 T265 D138 S139 I140 R168 I174 A175 G176 T177 MOAD: Kd=44uM
PDBbind-CN: -logKd/Ki=4.36,Kd=44uM
Gene Ontology
Molecular Function
GO:0000166 nucleotide binding
GO:0004748 ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0016491 oxidoreductase activity
GO:0042802 identical protein binding
Biological Process
GO:0009263 deoxyribonucleotide biosynthetic process
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005971 ribonucleoside-diphosphate reductase complex

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:3rsr, PDBe:3rsr, PDBj:3rsr
PDBsum3rsr
PubMed22933704
UniProtP21524|RIR1_YEAST Ribonucleoside-diphosphate reductase large chain 1 (Gene Name=RNR1)

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