Structure of PDB 3rs7 Chain A

Receptor sequence
>3rs7A (length=163) Species: 9606 (Homo sapiens) [Search protein sequence]
MTEYKLVVVGAGGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGET
CLLDILDTAGQEEYRDQYMRTGEGFLCVFAINNTKSFEDIHQYREQIKRV
KDSDDVPMVLVGNKCDLAARTVESRQAQDLARSYGIPYIETSAKTRQGVE
DAFYTLVREIRQH
3D structure
PDB3rs7 Analysis of Binding Site Hot Spots on the Surface of Ras GTPase.
ChainA
Resolution1.7 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.6.5.2: small monomeric GTPase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 GNP A G13 G15 K16 S17 A18 F28 V29 D30 Y32 T35 G60 N116 K117 D119 L120 S145 A146 G13 G15 K16 S17 A18 F28 V29 D30 Y32 T35 G60 N113 K114 D116 L117 S142 A143
BS02 CA A F28 D30 F28 D30
BS03 CA A R102 D105 R99 D102
BS04 MG A S17 T35 S17 T35
Gene Ontology
Molecular Function
GO:0003924 GTPase activity
GO:0005525 GTP binding
Biological Process
GO:0007165 signal transduction
Cellular Component
GO:0016020 membrane

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Cellular Component
External links
PDB RCSB:3rs7, PDBe:3rs7, PDBj:3rs7
PDBsum3rs7
PubMed21945529
UniProtP01112|RASH_HUMAN GTPase HRas (Gene Name=HRAS)

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