Structure of PDB 3rog Chain A

Receptor sequence
>3rogA (length=233) Species: 10090 (Mus musculus) [Search protein sequence]
AVKYLSQEEAQAVDQELFNEYQFSVDQLMELAGLSCATAIAKAYPPTSMS
KSPPTVLVICGPGNNGGDGLVCARHLKLFGYQPTIYYPKRPNKPLFTGLV
TQCQKMDIPFLGEMPPEPMMVDELYELVVDAIFGFSFKGDVREPFHSILS
VLSGLTVPIASIDIPSGWDVEKGNPSGIQPDLLISLTAPKKSATHFTGRY
HYLGGRFVPPALEKKYQLNLPSYPDTECVYRLQ
3D structure
PDB3rog Identification of unknown protein function using metabolite cocktail screening.
ChainA
Resolution2.05 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 5.1.99.6: NAD(P)H-hydrate epimerase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 T3P A A35 D39 L42 M54 N89 D93 F160 D188 L211 T212 K215 F232 A10 D14 L17 M29 N64 D68 F135 D163 L186 T187 K190 F207
Gene Ontology
Molecular Function
GO:0000166 nucleotide binding
GO:0016853 isomerase activity
GO:0042802 identical protein binding
GO:0046872 metal ion binding
GO:0052856 NAD(P)HX epimerase activity
Biological Process
GO:0002040 sprouting angiogenesis
GO:0006869 lipid transport
GO:0010874 regulation of cholesterol efflux
GO:0016525 negative regulation of angiogenesis
GO:0031580 membrane raft distribution
GO:0046496 nicotinamide nucleotide metabolic process
GO:0110051 metabolite repair
Cellular Component
GO:0005576 extracellular region
GO:0005615 extracellular space
GO:0005634 nucleus
GO:0005739 mitochondrion
GO:0005829 cytosol
GO:0005929 cilium
GO:0044297 cell body

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:3rog, PDBe:3rog, PDBj:3rog
PDBsum3rog
PubMed22940582
UniProtQ8K4Z3|NNRE_MOUSE NAD(P)H-hydrate epimerase (Gene Name=Naxe)

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