Structure of PDB 3rn2 Chain A

Receptor sequence
>3rn2A (length=194) Species: 9606 (Homo sapiens) [Search protein sequence]
EGFQKRCLPVMVLKAKKPFTFETQEGKQEMFHATVATEKEFFFVKVFNTL
LKDKFIPKRIIIIARYYRHSGFLEVNSASRVLDAESDQKVNVPLNIIRKA
GETPKINTLQTQPLGTIVNGLFVVQKVTEKKKNILFDLSDNTGKMEVLGV
RNEDTMKCKEGDKVRLTFFTLSKNGEKLQLTSGVHSTIKVIKAK
3D structure
PDB3rn2 Structures of the HIN Domain:DNA Complexes Reveal Ligand Binding and Activation Mechanisms of the AIM2 Inflammasome and IFI16 Receptor.
ChainA
Resolution2.55 Å
3D
structure
[Spin on]
[Spin off]
[Reset orientation]

[High quality]
[Low quality]

[White background]
[Black background]

[Download]
[Download structure with residue number starting from 1]
Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 dna A L267 K309 R311 K340 L121 K163 R165 K194 PDBbind-CN: Kd=0.112uM
BS02 dna A K162 K163 R244 N287 K16 K17 R98 N141 PDBbind-CN: Kd=0.112uM
Gene Ontology
Biological Process
GO:0002218 activation of innate immune response
GO:0035458 cellular response to interferon-beta

View graph for
Biological Process
External links
PDB RCSB:3rn2, PDBe:3rn2, PDBj:3rn2
PDBsum3rn2
PubMed22483801
UniProtO14862|AIM2_HUMAN Interferon-inducible protein AIM2 (Gene Name=AIM2)

[Back to BioLiP]