Structure of PDB 3rlh Chain A

Receptor sequence
>3rlhA (length=278) Species: 58218 (Loxosceles intermedia) [Search protein sequence]
GNRRPIWIMGHMVNAIGQIDEFVNLGANSIETDVSFDDNANPEYTYHGIP
CDCGRNCKKYENFNDFLKGLRSATTPGNSKYQEKLVLVVFDLKTGSLYDN
QANDAGKKLAKNLLQHYWNNGNNGGRAYIVLSIPDLNHYPLIKGFKDQLT
KDGHPELMDKVGHDFSGNDDIGDVGKAYKKAGITGHIWQSDGITNCLPRG
LSRVNAAVANRDSANGFINKVYYWTVDKRSTTRDALDAGVDGIMTNYPDV
ITDVLNEAAYKKKFRVATYDDNPWVTFK
3D structure
PDB3rlh Structure of a novel class II phospholipase D: Catalytic cleft is modified by a disulphide bridge.
ChainA
Resolution1.72 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) H12 E32 D34 H47 G48 D52 D91 K93 W230 D233 N252
Catalytic site (residue number reindexed from 1) H11 E31 D33 H47 G48 D52 D91 K93 W224 D227 N246
Enzyme Commision number 4.6.1.-
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 MG A E32 D34 D91 E31 D33 D91
Gene Ontology
Molecular Function
GO:0008081 phosphoric diester hydrolase activity
Biological Process
GO:0006629 lipid metabolic process

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Molecular Function
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Biological Process
External links
PDB RCSB:3rlh, PDBe:3rlh, PDBj:3rlh
PDBsum3rlh
PubMed21616057
UniProtP0CE80|A1HA_LOXIN Dermonecrotic toxin LiSicTox-alphaIA1a

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