Structure of PDB 3rig Chain A

Receptor sequence
>3rigA (length=260) Species: 9606 (Homo sapiens) [Search protein sequence]
SFTARPSSSMADFRKFFAKAKHIVIISGAGVGGYWRKWQAQDLATPLAFA
HNPSRVWEFYHYRREVMGSKEPNAGHRAIAECETRLGKQGRRVVVITQNI
DELHRKAGTKNLLEIHGSLFKTRCTSCGVVAENYKSPICPALSGKGAPEP
GTQDASIPVEKLPRCEEAGCGGLLRPHVVWFGENLDPAILEEVDRELAHC
DLCLVVGTSSVVYPAAMFAPQVAARGVPVAEFNTETTPATNRFRFHFQGP
CGTTLPEALA
3D structure
PDB3rig Sirt5 is a NAD-dependent protein lysine demalonylase and desuccinylase
ChainA
Resolution2.0 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) N141 D143 H158
Catalytic site (residue number reindexed from 1) N99 D101 H116
Enzyme Commision number 2.3.1.-
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 peptide A H158 V221 F223 G224 E225 N226 L227 V253 V254 Y255 P256 H116 V179 F181 G182 E183 N184 L185 V211 V212 Y213 P214
BS02 ZN A C166 C169 C207 C124 C127 C165
Gene Ontology
Molecular Function
GO:0036054 protein-malonyllysine demalonylase activity
GO:0036055 protein-succinyllysine desuccinylase activity
GO:0070403 NAD+ binding

View graph for
Molecular Function
External links
PDB RCSB:3rig, PDBe:3rig, PDBj:3rig
PDBsum3rig
PubMed22076378
UniProtQ9NXA8|SIR5_HUMAN NAD-dependent protein deacylase sirtuin-5, mitochondrial (Gene Name=SIRT5)

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