Structure of PDB 3rhn Chain A

Receptor sequence
>3rhnA (length=115) Species: 9986 (Oryctolagus cuniculus) [Search protein sequence]
RPGGDTIFGKIIRKEIPAKIIFEDDQCLAFHDISPQAPTHFLVIPKKHIS
QISAAEDADESLLGHLMIVGKKCAADLGLKKGYRMVVNEGSDGGQSVYHV
HLHVLGGRQMNWPPG
3D structure
PDB3rhn Crystal structures of HINT demonstrate that histidine triad proteins are GalT-related nucleotide-binding proteins.
ChainA
Resolution2.1 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.4.22.-
3.9.1.-
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 5GP A F41 D43 I44 N99 Q106 S107 V108 H112 H114 F30 D32 I33 N88 Q95 S96 V97 H101 H103
Gene Ontology
Molecular Function
GO:0000166 nucleotide binding
GO:0003824 catalytic activity
GO:0008234 cysteine-type peptidase activity
GO:0016787 hydrolase activity
GO:0016929 deSUMOylase activity
GO:0043530 adenosine 5'-monophosphoramidase activity
Biological Process
GO:0006355 regulation of DNA-templated transcription
GO:0006508 proteolysis
GO:0006915 apoptotic process
GO:0009154 purine ribonucleotide catabolic process
GO:0016926 protein desumoylation
GO:0072332 intrinsic apoptotic signaling pathway by p53 class mediator
Cellular Component
GO:0000118 histone deacetylase complex
GO:0005634 nucleus
GO:0005737 cytoplasm

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Cellular Component
External links
PDB RCSB:3rhn, PDBe:3rhn, PDBj:3rhn
PDBsum3rhn
PubMed9164465
UniProtP80912|HINT1_RABIT Adenosine 5'-monophosphoramidase HINT1 (Gene Name=HINT1)

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