Structure of PDB 3rep Chain A

Receptor sequence
>3repA (length=268) Species: 9606 (Homo sapiens) [Search protein sequence]
HSGIDFKQLNFLTKLNENHSGELWKGRWQGNDIVVKVLKVRDWSTRKSRD
FNEECPRLRIFSHPNVLPVLGACQSPPAPHPTLITHWMPYGSLYNVLHEG
TNFVVDQSQAVKFALDMARGMAFLHTLEPLIPRHALNSRSVMIDEDMTAR
ISMADVKFSFQSPGRMYAPAWVAPEALQKKPEDTNRRSADMWSFAVLLWE
LVTREVPFADLSNMEIGMKVALEGLRPTIPPGISPHVSKLMKICMNEDPA
KRPKFDMIVPILEKMQDK
3D structure
PDB3rep Crystal structure of the ILK/alpha-parvin core complex (MnATP)
ChainA
Resolution1.8 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) H318 S322 R323
Catalytic site (residue number reindexed from 1) H134 S138 R139
Enzyme Commision number 2.7.11.1: non-specific serine/threonine protein kinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ATP A N200 N202 S204 L207 V218 K220 W271 M272 N279 M326 D339 K341 N16 N18 S20 L23 V34 K36 W87 M88 N95 M142 D155 K157
Gene Ontology
Molecular Function
GO:0004672 protein kinase activity
GO:0005524 ATP binding
Biological Process
GO:0006468 protein phosphorylation

View graph for
Molecular Function
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Biological Process
External links
PDB RCSB:3rep, PDBe:3rep, PDBj:3rep
PDBsum3rep
PubMed
UniProtQ13418|ILK_HUMAN Integrin-linked protein kinase (Gene Name=ILK)

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