Structure of PDB 3rcj Chain A

Receptor sequence
>3rcjA (length=282) Species: 9606 (Homo sapiens) [Search protein sequence]
KRPEDFKFGKILGEGSFSTVVLARELATSREYAIKILEKRHIIKENKVPY
VTRERDVMSRLDHPFFVKLYFTFQDDEKLYFGLSYAKNGELLKYIRKIGS
FDETCTRFYTAEIVSALEYLHGKGIIHRDLKPENILLNEDMHIQITDFGT
AKVLSPESKQARANSFVGTAQYVSPELLTEKSACKSSDLWALGCIIYQLV
AGLPPFRAGNEGLIFAKIIKLEYDFPEKFFPKARDLVEKLLVLDATKRLG
CEEMEGYGPLKAHPFFESVTWENLHQQTPPKL
3D structure
PDB3rcj Rapid preparation of triazolyl substituted NH-heterocyclic kinase inhibitors via one-pot Sonogashira coupling-TMS-deprotection-CuAAC sequence.
ChainA
Resolution1.7 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) D205 K207 E209 N210 D223 T245
Catalytic site (residue number reindexed from 1) D129 K131 E133 N134 D147 T169
Enzyme Commision number 2.7.11.1: non-specific serine/threonine protein kinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 3RC A S94 V96 A109 S160 Y161 A162 L212 T222 S18 V20 A33 S84 Y85 A86 L136 T146 MOAD: ic50=0.8uM
PDBbind-CN: -logKd/Ki=6.10,IC50=0.8uM
Gene Ontology
Molecular Function
GO:0004672 protein kinase activity
GO:0004674 protein serine/threonine kinase activity
GO:0005524 ATP binding
Biological Process
GO:0006468 protein phosphorylation

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Molecular Function
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Biological Process
External links
PDB RCSB:3rcj, PDBe:3rcj, PDBj:3rcj
PDBsum3rcj
PubMed21625704
UniProtO15530|PDPK1_HUMAN 3-phosphoinositide-dependent protein kinase 1 (Gene Name=PDPK1)

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