Structure of PDB 3rc4 Chain A

Receptor sequence
>3rc4A (length=199) [Search protein sequence]
HMASMKKKGSVVIVGRINLSGDTAYAQQTRGEEGCQETSQTGRDKNQVEG
EVQIVSTATQTFLATSINGVLWTVYHGAGTRTIASPKGPVTQMYTNVDKD
LVGWQAPQGSRSLTPCTCGSSDLYLVTRHADVIPVRRRGDSRGSLLSPRP
ISYLKGSAGGPLLCPAGHAVGIFRAAVSTRGVAKAVDFIPVESLETTMR
3D structure
PDB3rc4 Molecular mechanisms of viral and host cell substrate recognition by hepatitis C virus NS3/4A protease.
ChainA
Resolution1.5 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) H1057 D1081 G1137 A1139
Catalytic site (residue number reindexed from 1) H76 D100 G156 A158
Enzyme Commision number 2.7.7.48: RNA-directed RNA polymerase.
3.4.21.98: hepacivirin.
3.4.22.-
3.6.1.15: nucleoside-triphosphate phosphatase.
3.6.4.13: RNA helicase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 peptide A H1057 L1135 G1137 A1139 F1154 A1156 A1157 V1158 S1159 T1160 H76 L154 G156 A158 F173 A175 A176 V177 S178 T179
BS02 ZN A C1097 C1099 C1145 H1149 C116 C118 C164 H168
Gene Ontology
Molecular Function
GO:0008236 serine-type peptidase activity
Biological Process
GO:0006508 proteolysis
GO:0019087 transformation of host cell by virus

View graph for
Molecular Function
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Biological Process
External links
PDB RCSB:3rc4, PDBe:3rc4, PDBj:3rc4
PDBsum3rc4
PubMed21507982
UniProtP27958|POLG_HCV77 Genome polyprotein

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