Structure of PDB 3r8d Chain A

Receptor sequence
>3r8dA (length=264) Species: 9606 (Homo sapiens) [Search protein sequence]
GLTEEQRMMIRELMDAQMKTFDTTFSHFKNFRLPGKWSQVRKDLCSLKVS
LQLRGEDGSVWNYKPPADSGGKEIFSLLPHMADMSTYMFKGIISFAKVIS
YFRDLPIEDQISLLKGAAFELCQLRFNTVFNAETGTWECGRLSYCLEFQQ
LLLEPMLKFHYMLKKLQLHEEEYVLMQAISLFSPDRPGVLQHRVVDQLQE
QFAITLKSYIECNRPQPAHRFLFLKIMAMLTELRSINAQHTQRLLRIQDI
HPFATPLMQELFGI
3D structure
PDB3r8d Activation of the human nuclear xenobiotic receptor PXR by the reverse transcriptase-targeted anti-HIV drug PNU-142721.
ChainA
Resolution2.8 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.3.1.48: histone acetyltransferase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 PNU A L240 M243 S247 Q285 F288 W299 L411 F420 L78 M81 S85 Q123 F126 W137 L244 F253
Gene Ontology
Molecular Function
GO:0003677 DNA binding
GO:0004879 nuclear receptor activity
Biological Process
GO:0006355 regulation of DNA-templated transcription

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Molecular Function
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Biological Process
External links
PDB RCSB:3r8d, PDBe:3r8d, PDBj:3r8d
PDBsum3r8d
PubMed21805522
UniProtO75469|NR1I2_HUMAN Nuclear receptor subfamily 1 group I member 2 (Gene Name=NR1I2)

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