Structure of PDB 3r7o Chain A

Receptor sequence
>3r7oA (length=301) Species: 9606 (Homo sapiens) [Search protein sequence]
QNTVHIDLSALNPELVQAVQHVVIGPSSLIVHFNEVIGRGHFGCVYHGTL
LDNDGKKIHCAVKSLNRITDIGEVSQFLTEGIIMKDFSHPNVLSLLGICL
RSEGSPLVVLPYMKHGDLRNFIRNETHNPTVKDLIGFGLQVAKGMKYLAS
KKFVHRDLAARNCMLDEKFTVKVADFGLARDMYDKEYYSVHNKLPVKWMA
LESLQTQKFTTKSDVWSFGVLLWELMTRGAPPYPDVNTFDITVYLLQGRR
LLQPEYCPDPLYEVMLKCWHPKAEMRPSFSELVSRISAIFSTFIGEHHHH
H
3D structure
PDB3r7o Structural basis for selective small molecule kinase inhibition of activated c-Met.
ChainA
Resolution2.3 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) D1204 A1206 R1208 N1209 D1222
Catalytic site (residue number reindexed from 1) D157 A159 R161 N162 D175
Enzyme Commision number 2.7.10.1: receptor protein-tyrosine kinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 M61 A I1084 G1085 R1086 V1092 A1108 Y1159 M1160 K1161 G1163 D1164 R1208 M1211 D1222 I37 G38 R39 V45 A61 Y112 M113 K114 G116 D117 R161 M164 D175 PDBbind-CN: -logKd/Ki=8.36,Kd=4.4nM
BindingDB: IC50=3.0nM
Gene Ontology
Molecular Function
GO:0004672 protein kinase activity
GO:0004713 protein tyrosine kinase activity
GO:0005524 ATP binding
Biological Process
GO:0006468 protein phosphorylation

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Molecular Function
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Biological Process
External links
PDB RCSB:3r7o, PDBe:3r7o, PDBj:3r7o
PDBsum3r7o
PubMed21247903
UniProtP08581|MET_HUMAN Hepatocyte growth factor receptor (Gene Name=MET)

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