Structure of PDB 3r5m Chain A

Receptor sequence
>3r5mA (length=215) Species: 9606 (Homo sapiens) [Search protein sequence]
NEDMPVERILEAELAVEPNDPVTNICQAADKQLFTLVEWAKRIPHFSELP
LDDQVILLRAGWNELLIASFSHRSIAVKDGILLATGLHVHRNSAHSAGVG
AIFDRVLTELVSKMRDMQMDKTELGCLRAIVLFNPDSKGLSNPAEVEALR
EKVYASLEAYCKHKYPEQPGRFAKLLLRLPALRSIGLKCLEHLFFFKLIG
DTPIDTFLMEMLEAP
3D structure
PDB3r5m Molecular determinants of magnolol targeting both RXR(alpha) and PPAR(gamma).
ChainA
Resolution2.8 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 peptide A F277 K284 Q297 V298 L301 R302 T449 F450 E453 F34 K41 Q54 V55 L58 R59 T206 F207 E210
BS02 MLO A I268 A272 L309 F313 F346 C432 L436 I25 A29 L66 F70 F103 C189 L193 PDBbind-CN: -logKd/Ki=4.34,Kd=45.7uM
Gene Ontology
Molecular Function
GO:0003677 DNA binding
GO:0003707 nuclear steroid receptor activity
GO:0008270 zinc ion binding
Biological Process
GO:0006355 regulation of DNA-templated transcription
Cellular Component
GO:0005634 nucleus

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Molecular Function
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Cellular Component
External links
PDB RCSB:3r5m, PDBe:3r5m, PDBj:3r5m
PDBsum3r5m
PubMed22140563
UniProtP19793|RXRA_HUMAN Retinoic acid receptor RXR-alpha (Gene Name=RXRA)

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