Structure of PDB 3r30 Chain A

Receptor sequence
>3r30A (length=264) Species: 9606 (Homo sapiens) [Search protein sequence]
FHVKSGLQIKKNAIIDDYKVTSQVLGLGIGKVLQIFNKRTQEKFALKMLQ
DCPKARREVELHWRASQCPHIVRIVDVYENLYAGRKCLLIVMECLDGGEL
FSRIQDTEREASEIMKSIGEAIQYLHSINIAHRDVKPENLLYTSKRPNAI
LKLTDFGFAKETTPEVLDKSCDMWSLGVIMYILLCGYPPFYSGMKTRIRM
GQYEFPNPEWSEVSEEVKMLIRNLLKTEPTQRMTITEFMNHPWIMQSTKV
PQTPLHTSRVLKED
3D structure
PDB3r30 Structure-based lead identification of ATP-competitive MK2 inhibitors.
ChainA
Resolution3.2 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) D186 K188 E190 N191 D207
Catalytic site (residue number reindexed from 1) D134 K136 E138 N139 D155
Enzyme Commision number 2.7.11.1: non-specific serine/threonine protein kinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 CD2 A L70 K93 C140 L141 E190 L193 D207 L25 K47 C94 L95 E138 L141 D155 BindingDB: EC50=28nM
Gene Ontology
Molecular Function
GO:0004672 protein kinase activity
GO:0005524 ATP binding
Biological Process
GO:0006468 protein phosphorylation

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Molecular Function
View graph for
Biological Process
External links
PDB RCSB:3r30, PDBe:3r30, PDBj:3r30
PDBsum3r30
PubMed21565500
UniProtP49137|MAPK2_HUMAN MAP kinase-activated protein kinase 2 (Gene Name=MAPKAPK2)

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