Structure of PDB 3r1n Chain A

Receptor sequence
>3r1nA (length=274) Species: 9606 (Homo sapiens) [Search protein sequence]
EPKKYAVTDDYQLSKQVLGLGVNGKVLECFHRRTGQKCALKLLYDSPKAR
QEVDHHWQASGGPHIVCILDVYENMHHGKRCLLIIMECMEGGELFSRIQE
RGAFTEREAAEIMRDIGTAIQFLHSHNIAHRDVKPENLLYTSKEKDAVLK
LTDFGFAKETTPEKYDKSCDMWSLGVIMYILLCGFPPFYGFPNPEWSEVS
EDAKQLIRLLLKTDPTERLTITQFMNHPWINQSMVVPQTPLHTARVLQED
KDHWDEVKEEMTSALATMRVDYDQ
3D structure
PDB3r1n Structure-based lead identification of ATP-competitive MK2 inhibitors.
ChainA
Resolution2.09 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) D166 K168 N171 D187
Catalytic site (residue number reindexed from 1) D132 K134 N137 D153
Enzyme Commision number 2.7.11.1: non-specific serine/threonine protein kinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 05B A L50 G51 L52 G53 V58 A71 K73 C120 M121 E122 G124 E170 L173 T186 D187 L18 G19 L20 G21 V26 A39 K41 C88 M89 E90 G92 E136 L139 T152 D153
Gene Ontology
Molecular Function
GO:0004672 protein kinase activity
GO:0005524 ATP binding
Biological Process
GO:0006468 protein phosphorylation

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Molecular Function
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Biological Process
External links
PDB RCSB:3r1n, PDBe:3r1n, PDBj:3r1n
PDBsum3r1n
PubMed21565500
UniProtQ16644|MAPK3_HUMAN MAP kinase-activated protein kinase 3 (Gene Name=MAPKAPK3)

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