Structure of PDB 3qx8 Chain A

Receptor sequence

>3qx8A (length=133) Species: 9606 (Homo sapiens)

KQFHTGIEIKVWAIACFAPQRQCTEVHLKSFTEQLRKISRDAGMPIQGQP
CFCKYAQGADSVEPMFRHLKNTYAGLQLVVVILPGKTPVYAEVKRVGDTV
LGMATQCVQMKNVQRTTPQTLSNLCLKINVKLG

3D structure

• PDB: 3qx8 Structural analysis of 5'-mRNA-cap interactions with the human AGO2 MID domain.
• Chain: A
• Resolution: 2.3 Å

Enzymatic activity

• Enzyme Commision number: 3.1.26.n2: argonaute-2.

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	GTG	A	L522 G524 K525 T526 Y529 K533 Q545 C546 Q548 K570	L83 G85 K86 T87 Y90 K94 Q106 C107 Q109 K131	MOAD: Kd=1.37mM PDBbind-CN: -logKd/Ki=2.86,Kd=1.37mM

Gene Ontology

Molecular Function

• GO:0003676 nucleic acid binding

External links

• PDB: RCSB:3qx8, PDBe:3qx8, PDBj:3qx8
• PDBsum: 3qx8
• PubMed: 21475248
• UniProt: Q9UKV8|AGO2_HUMAN Protein argonaute-2 (Gene Name=AGO2)