Structure of PDB 3qv8 Chain A

Receptor sequence
>3qv8A (length=396) Species: 5665 (Leishmania mexicana) [Search protein sequence]
SQLAHNLTLSIFDPVANYRAARIICTIGPSTQSVEALKGLIQSGMSVARM
NFSHGSHEYHQTTINNVRQAAAELGVNIAIALDTKGPDVDLPAVSAKDRV
DLQFGVEQGVDMIFASFIRSAEQVGDVRKALGPKGRDIMIICKIENHQGV
QNIDSIIEESDGIMVARGDLGVEIPAEKVVVAQKILISKCNVAGKPVICA
TQMLESMTYNPRPTRAEVSDVANAVFNGADCVMLSGETAKGKYPNEVVQY
MARICLEAQSALNEYVFFNSIKKLQHIPMSADEAVCSSAVNSVYETKAKA
MVVLSNTGRSARLVAKYRPNCPIVCVTTRLQTCRQLNITQGVESVFFDAD
KLGHDEGKEHRVAAGVEFAKSKGYVQTGDYCVVIHAANQTRILLVE
3D structure
PDB3qv8 The trypanocidal drug suramin and other trypan blue mimetics are inhibitors of pyruvate kinases and bind to the adenosine site.
ChainA
Resolution2.45 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) R49 K238 T296
Catalytic site (residue number reindexed from 1) R49 K143 T201
Enzyme Commision number 2.7.1.40: pyruvate kinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 S62 A T26 P29 N51 G331 T26 P29 N51 G236
Gene Ontology
Molecular Function
GO:0000287 magnesium ion binding
GO:0003824 catalytic activity
GO:0004743 pyruvate kinase activity
GO:0005524 ATP binding
GO:0016301 kinase activity
GO:0030955 potassium ion binding
GO:0046872 metal ion binding
Biological Process
GO:0006096 glycolytic process
GO:0016310 phosphorylation
Cellular Component
GO:0005737 cytoplasm

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Cellular Component
External links
PDB RCSB:3qv8, PDBe:3qv8, PDBj:3qv8
PDBsum3qv8
PubMed21733839
UniProtQ27686|KPYK_LEIME Pyruvate kinase (Gene Name=PYK)

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