Structure of PDB 3qt6 Chain A

Receptor sequence
>3qt6A (length=328) Species: 1282 (Staphylococcus epidermidis) [Search protein sequence]
SMVKSGKARAHTNIALIKYWGKADETYIIPMNNSLSVTLDRFYTETKVTF
DPDFTEDCLILNGNEVNAKEKEKIQNYMNIVRDLAGNRLHARIESENYVP
TAAGLASSASAYAALAAACNEALSLNLSDTDLSRLARRGSGSASRSIFGG
FAEWEKGHDDLTSYAHGINSNGWEKDLSMIFVVINNQSKKVSSRSGMSLT
RDTSRFYQYWLDHVDEDLNEAKEAVKNQDFQRLGEVIEANGLRMHATNLG
AQPPFTYLVQESYDAMAIVEQCRKANLPCYFTMDAGPNVKVLVEKKNKQA
VMEQFLKVFDESKIIASDIISSGVEIIK
3D structure
PDB3qt6 Crystal structures of Staphylococcus epidermidis mevalonate diphosphate decarboxylase bound to inhibitory analogs reveal new insight into substrate binding and catalysis.
ChainA
Resolution2.047 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 4.1.1.33: diphosphomevalonate decarboxylase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 2P0 A K17 Y18 K21 S139 G140 S141 R144 S192 R193 D283 K18 Y19 K22 S140 G141 S142 R145 S193 R194 D284 MOAD: Ki=4.3uM
PDBbind-CN: -logKd/Ki=5.37,Ki=4.3uM
Gene Ontology
Molecular Function
GO:0004163 diphosphomevalonate decarboxylase activity
GO:0005524 ATP binding
GO:0016301 kinase activity
GO:0016829 lyase activity
GO:0016831 carboxy-lyase activity
Biological Process
GO:0006629 lipid metabolic process
GO:0008299 isoprenoid biosynthetic process
GO:0016310 phosphorylation
GO:0019287 isopentenyl diphosphate biosynthetic process, mevalonate pathway
Cellular Component
GO:0005829 cytosol

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:3qt6, PDBe:3qt6, PDBj:3qt6
PDBsum3qt6
PubMed21561869
UniProtQ9FD73

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