Structure of PDB 3qqx Chain A

Receptor sequence
>3qqxA (length=474) Species: 83333 (Escherichia coli K-12) [Search protein sequence]
AERPTLPIPDLLTTDARNRIQLTIGAGQSTFGGKTATTWGYNGNLLGPAV
KLQRGKAVTVDIYNQLTEETTLHWHGLEVPGEVDGGPQGIIPPGGKRSVT
LNVDQPAATCWFHPHQHGKTGRQVAMGLAGLVVIEDDEILKLMLPKQWGI
DDVPVIVQDKKFSADGQIDYQLDVMTAAVGWFGDTLLTNGAIYPQHAAPR
GWLRLRLLNGCNARSLNFATSDNRPLYVIASDGGLLPEPVKVSELPVLMG
ERFEVLVEVNDNKPFDLVTLPVSQMGMAIAPFDKPHPVMRIQPIAISASG
ALPDTLSSLPALPSLEGLTVRKLQLSMDPMLDMMGMQMLMEKYGDQAMAG
MDHFDFHHANKINGQAFDMNKPMFAAAKGQYERWVISGVGDMMLHPFHIH
GTQFRILSENGKPPAAHRAGWKDTVKVEGNVSEVLVKFNHDAPKEHAYMA
HCHLLEHDDTGMMLGFTVLQGDHG
3D structure
PDB3qqx CueO E506D Mutant: Crystal Structure of Reduced Native Intermediate, Kinetics, and Impairment of Product Release
ChainA
Resolution1.5 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) H101 H103 H141 H143
Catalytic site (residue number reindexed from 1) H73 H75 H113 H115
Enzyme Commision number 1.16.3.4: cuproxidase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 CU A H101 H446 H448 H73 H398 H400
BS02 CU A H143 H448 H499 H115 H400 H451
BS03 CU1 A H103 H141 H501 H75 H113 H453
BS04 CU1 A H443 C500 H505 H395 C452 H457
BS05 CU1 A M355 D360 D439 M441 M327 D332 D391 M393
BS06 CU1 A M358 M362 H398 M330 M334 H353
BS07 CU1 A M368 M376 M340 M348
BS08 O A H101 H446 H448 H73 H398 H400
BS09 O A H141 H499 H501 H113 H451 H453
Gene Ontology
Molecular Function
GO:0004322 ferroxidase activity
GO:0005507 copper ion binding
GO:0016491 oxidoreductase activity
GO:0016682 oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
GO:0016722 oxidoreductase activity, acting on metal ions
GO:0016724 oxidoreductase activity, acting on metal ions, oxygen as acceptor
GO:0046872 metal ion binding
Biological Process
GO:0010273 detoxification of copper ion
GO:0046688 response to copper ion
Cellular Component
GO:0030288 outer membrane-bounded periplasmic space
GO:0042597 periplasmic space

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:3qqx, PDBe:3qqx, PDBj:3qqx
PDBsum3qqx
PubMed
UniProtP36649|CUEO_ECOLI Multicopper oxidase CueO (Gene Name=cueO)

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