Structure of PDB 3qpw Chain A

Receptor sequence
>3qpwA (length=431) Species: 9606 (Homo sapiens) [Search protein sequence]
ELTQSRVQKIWVPVDHRPSLPRSNSPTVIVMVGLPARGKTYISKKLTRYL
NWIGVPTKVFNVGEYRREAVKQYSSYNFFRPDNEEAMKVRKQCALAALRD
VKSYLAKEGGQIAVFDATNTTRERRHMILHFAKENDFKAFFIESVCDDPT
VVASNIMEVKISSPDYKDCNSAEAMDDFMKRISCYEASYQPLDPDKCDRD
LSLIKVIDVGRRFLVNRVQDHIQSRIVYYLMNIHVQPRTIYLCRHGENEH
NLQGRIGGDSGLSSRGKKFASALSKFVEEQNLKDLRVWTSQLKSTIQTAE
ALRLPYEQWKALNEIDAGVCEELTYEEIRDTYPEEYALREQDKYYYRYPT
GESYQDLVQRLEPVIMELERQENVLVICHQAVLRCLLAYFLDKSAEEMPY
LKCPLHTVLKLTPVAYGCRVESIYLNVESVC
3D structure
PDB3qpw Molecular basis of the fructose-2,6-bisphosphatase reaction of PFKFB3: Transition state and the C-terminal function.
ChainA
Resolution2.25 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) R252 H253 N259 S302 E322 H387
Catalytic site (residue number reindexed from 1) R244 H245 N251 S294 E314 H379
Enzyme Commision number 2.7.1.105: 6-phosphofructo-2-kinase.
3.1.3.46: fructose-2,6-bisphosphate 2-phosphatase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ALF A R252 H253 H387 Q388 R244 H245 H379 Q380
BS02 ADP A A44 R45 G46 K47 T48 Y49 S152 N163 E166 V167 K168 V243 Y424 A36 R37 G38 K39 T40 Y41 S144 N155 E158 V159 K160 V235 Y416
BS03 PEP A G71 R74 F87 R98 T126 Y193 G63 R66 F79 R90 T118 Y185
Gene Ontology
Molecular Function
GO:0003824 catalytic activity
GO:0003873 6-phosphofructo-2-kinase activity
GO:0004331 fructose-2,6-bisphosphate 2-phosphatase activity
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0016301 kinase activity
GO:0016787 hydrolase activity
Biological Process
GO:0006000 fructose metabolic process
GO:0006003 fructose 2,6-bisphosphate metabolic process
GO:0006096 glycolytic process
GO:0006915 apoptotic process
GO:0010001 glial cell differentiation
GO:0016310 phosphorylation
GO:0046835 carbohydrate phosphorylation
GO:0061744 motor behavior
Cellular Component
GO:0005654 nucleoplasm
GO:0005829 cytosol

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:3qpw, PDBe:3qpw, PDBj:3qpw
PDBsum3qpw
PubMed22275052
UniProtQ16875|F263_HUMAN 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3 (Gene Name=PFKFB3)

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