Structure of PDB 3qpu Chain A

Receptor sequence
>3qpuA (length=439) Species: 9606 (Homo sapiens) [Search protein sequence]
ELTQSRVQKIWVPVDHRPSLPRSCGSPTVIVMVGLPARGKTYISKKLTRY
LNWIGVPTKVFNVGEYRREAVKQYSSYNFFRPDNEEAMKVRKQCALAALR
DVKSYLAKEGGQIAVFDATNTTRERRHMILHFAKENDFKAFFIESVCDDP
TVVASNIMEVKISSPDYKDCNSAEAMDDFMKRISCYEASYQPLDPDKCDR
DLSLIKVIDVGRRFLVNRVQDHIQSRIVYYLMNIHVQPRTIYLCRHGENE
HNLQGRIGGDSGLSSRGKKFASALSKFVEEQNLKDLRVWTSQLKSTIQTA
EALRLPYEQWKALNEIDAGVCEELTYEEIRDTYPEEYALREQDKYYYRYP
TGESYQDLVQRLEPVIMELERQENVLVICHQAVLRCLLAYFLDKSAEEMP
YLKCPLHTVLKLTPVAYGCRVESIYLNVESVCTHRERSE
3D structure
PDB3qpu Molecular basis of the fructose-2,6-bisphosphatase reaction of PFKFB3: Transition state and the C-terminal function.
ChainA
Resolution2.3 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) R252 H253 N259 S302 E322 H387
Catalytic site (residue number reindexed from 1) R245 H246 N252 S295 E315 H380
Enzyme Commision number 2.7.1.105: 6-phosphofructo-2-kinase.
3.1.3.46: fructose-2,6-bisphosphate 2-phosphatase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 POP A G71 R74 R98 T126 Y193 G64 R67 R91 T119 Y186
BS02 POP A P43 A44 R45 G46 K47 T48 Y49 V167 K168 Y424 P36 A37 R38 G39 K40 T41 Y42 V160 K161 Y417
BS03 POP A R252 H253 E322 H387 Q388 R245 H246 E315 H380 Q381
Gene Ontology
Molecular Function
GO:0003824 catalytic activity
GO:0003873 6-phosphofructo-2-kinase activity
GO:0004331 fructose-2,6-bisphosphate 2-phosphatase activity
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0016301 kinase activity
GO:0016787 hydrolase activity
Biological Process
GO:0006000 fructose metabolic process
GO:0006003 fructose 2,6-bisphosphate metabolic process
GO:0006096 glycolytic process
GO:0006915 apoptotic process
GO:0010001 glial cell differentiation
GO:0016310 phosphorylation
GO:0046835 carbohydrate phosphorylation
GO:0061744 motor behavior
Cellular Component
GO:0005654 nucleoplasm
GO:0005829 cytosol

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:3qpu, PDBe:3qpu, PDBj:3qpu
PDBsum3qpu
PubMed22275052
UniProtQ16875|F263_HUMAN 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3 (Gene Name=PFKFB3)

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