Structure of PDB 3qox Chain A

Receptor sequence
>3qoxA (length=326) Species: 9606 (Homo sapiens) [Search protein sequence]
LELRLKSPVGAEPAVYPWPLPVYDKHHDAAHEIIETIRWVCEEIPDLKLA
MENLIDYDTKSFESMQRLCDKYNRAIDSIHQLWKGTTQPMKLNTRPSTGL
LRHILQQVYNHSVTDPEKLNNYEPFSPEVYGETSFDLVAQMIDEIKMTDD
DLFVDLGSGVGQVVLQVAAATNCKHHYGVEKADIPAKYAETMDREFRKWM
KWYGKKHAEYTLERGDFLSEEWRERIANTSVIFVNNFAFGPEVDHQLKER
FANMKEGGRIVSSKPFAPLNFRINSRNLSDIGTIMRVVELSPLKGSVSWT
GKPVSYYLHTIDRTILENYFSSLKNP
3D structure
PDB3qox Chemogenetic analysis of human protein methyltransferases.
ChainA
Resolution2.3 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.1.1.360: [histone H3]-lysine(79) N-trimethyltransferase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 SAH A P133 G137 E138 T139 D161 G163 S164 E186 K187 D222 F223 N241 F245 P127 G131 E132 T133 D155 G157 S158 E180 K181 D216 F217 N235 F239 MOAD: Ki=0.27uM
PDBbind-CN: -logKd/Ki=6.57,Ki=0.27uM
BindingDB: Ki=160nM,IC50=600nM,Kd=150nM
Gene Ontology
Molecular Function
GO:0031151 histone H3K79 methyltransferase activity
Biological Process
GO:0051726 regulation of cell cycle

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Molecular Function
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Biological Process
External links
PDB RCSB:3qox, PDBe:3qox, PDBj:3qox
PDBsum3qox
PubMed21564555
UniProtQ8TEK3|DOT1L_HUMAN Histone-lysine N-methyltransferase, H3 lysine-79 specific (Gene Name=DOT1L)

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