Structure of PDB 3qmk Chain A

Receptor sequence
>3qmkA (length=195) Species: 9606 (Homo sapiens) [Search protein sequence]
DGVDIYFGMPGEISEHEGFLRAKMDLEERRMRQINEVMREWAMADNQSKN
LPKADRQALNEHFQSILQTLEEQVSGERQRLVETHATRVIALINDQRRAA
LEGFLAALQADPPQAERVLLALRRYLRAEQKEQRHTLRHYQHVAAVDPEK
AQQMRFQVHTHLQVIEERVNQSLGLLDQNPHLAQELRPQIQELLH
3D structure
PDB3qmk Crystal structure of amyloid precursor-like protein 1 and heparin complex suggests a dual role of heparin in E2 dimerization.
ChainA
Resolution2.21 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 SGN A H307 K422 H16 K131 PDBbind-CN: -logKd/Ki=6.10,Kd=0.787uM
BS02 IDS A H307 H426 R429 H16 H135 R138 PDBbind-CN: -logKd/Ki=6.10,Kd=0.787uM
BS03 SGN A R429 H430 H433 R138 H139 H142 PDBbind-CN: -logKd/Ki=6.10,Kd=0.787uM
BS04 IDS A F310 V373 H433 F19 V82 H142 PDBbind-CN: -logKd/Ki=6.10,Kd=0.787uM
Gene Ontology

View graph for
Cellular Component
External links
PDB RCSB:3qmk, PDBe:3qmk, PDBj:3qmk
PDBsum3qmk
PubMed21930949
UniProtP51693|APLP1_HUMAN Amyloid beta precursor like protein 1 (Gene Name=APLP1)

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