Structure of PDB 3qkd Chain A

Receptor sequence
>3qkdA (length=140) Species: 9606 (Homo sapiens) [Search protein sequence]
SNRELVVDFLSYKLSQKGYSWSQFSSEAVKQALREAGDEFELRYRRAFSD
LTSQLHITPGTAYQSFEQVVNELFRDGVNWGRIVAFFSFGGALCVESVDK
EMQVLVSRIAAWMATYLNDHLEPWIQENGGWDTFVELYGN
3D structure
PDB3qkd Quinazoline sulfonamides as dual binders of the proteins B-cell lymphoma 2 and B-cell lymphoma extra long with potent proapoptotic cell-based activity.
ChainA
Resolution2.02 Å
3D
structure
[Spin on]
[Spin off]
[Reset orientation]

[High quality]
[Low quality]

[White background]
[Black background]

[Download]
[Download structure with residue number starting from 1]
Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 HI0 A A93 E96 F97 R100 Y101 F105 V126 E129 L130 G138 R139 V141 Y195 A36 E39 F40 R43 Y44 F48 V69 E72 L73 G81 R82 V84 Y138 MOAD: ic50=3nM
PDBbind-CN: -logKd/Ki=8.38,Kd=4.2nM
BindingDB: IC50=7nM,Kd=4.2nM
Gene Ontology
Biological Process
GO:0042981 regulation of apoptotic process

View graph for
Biological Process
External links
PDB RCSB:3qkd, PDBe:3qkd, PDBj:3qkd
PDBsum3qkd
PubMed21366295
UniProtQ07817|B2CL1_HUMAN Bcl-2-like protein 1 (Gene Name=BCL2L1)

[Back to BioLiP]