Structure of PDB 3qi5 Chain A

Receptor sequence
>3qi5A (length=206) Species: 9606 (Homo sapiens) [Search protein sequence]
GPHMTRLGLEFFDQPAVPLARAFLGQVLVRRLPNGTELRGRIVETEAYLG
PEDEAAHSRGGRQTPRNRGMFMKPGTLYVYIIYGMYFCMNISSQGDGACV
LLRALEPLEGLETMRQLRSTLRKVLKDRELCSGPSKLCQALAINKSFDQR
DLAQDEAVWLERGPLEPSEPAVVAAARVGVEWARKPLRFYVRGSPWVSVV
DRVAEQ
3D structure
PDB3qi5 Structural Basis for the Inhibition of Human Alkyladenine DNA Glycosylase (AAG) by 3,N4-Ethenocytosine-containing DNA.
ChainA
Resolution2.2 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.2.2.21: DNA-3-methyladenine glycosylase II.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 dna A Y127 H136 M149 Y159 I161 Y162 Y165 N169 L180 R197 K202 G217 P218 S219 K220 G263 Y48 H57 M70 Y80 I82 Y83 Y86 N90 L101 R118 K123 G133 P134 S135 K136 G179 PDBbind-CN: Kd=21nM
BS02 dna A T143 R145 Y162 G163 M164 K229 T64 R66 Y83 G84 M85 K145 PDBbind-CN: Kd=21nM
Gene Ontology
Molecular Function
GO:0003677 DNA binding
GO:0003824 catalytic activity
GO:0003905 alkylbase DNA N-glycosylase activity
Biological Process
GO:0006284 base-excision repair

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Molecular Function
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Biological Process
External links
PDB RCSB:3qi5, PDBe:3qi5, PDBj:3qi5
PDBsum3qi5
PubMed21349833
UniProtP29372|3MG_HUMAN DNA-3-methyladenine glycosylase (Gene Name=MPG)

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