Structure of PDB 3qgh Chain A

Receptor sequence
>3qghA (length=559) [Search protein sequence]
SMSYSWTGALVTPCAAEEQKLPINALSNSLLRHHNLVYSTTSRSACQRQK
KVTFDRLQVLDSHYQDVLKEVKAAASKVKANLLSVEEACSLTPPHSAKSK
FGYGAKDVRCHARKAVAHINSVWKDLLEDSVTPIDTTIMAKNEVFCVQPE
KRKPARLIVFPDLGVRVCEKMALYDVVSKLPLAVMGSSYGFQYSPGQRVE
FLVQAWKSKKTPMGFSYDTRCFDSTVTESDIRTEEAIYQCCDLDPQARVA
IKSLTERLYVGGPLTNSRGENCGYRRCRASGVLTTSCGNTLTCYIKARAA
CRAAGLQDCTMLVCGDDLVVICESAGVQEDAASLRAFTEAMTRYSAPPGD
PPQPEYDLELITSCSSNVSVAHDGAGKRVYYLTRDPTTPLARAAWETARH
TPVNSWLGNIIMFAPTLWARMILMTHFFSVLIARDQLEQALNCEIYGACY
SIEPLDLPPIIQRLHGLSAFSLHSYSPGEINRVAACLRKLGVPPLRAWRH
RARSVRARLLSRGGRAAICGKYLFNWAVRTKLKLTPIAAAGRLDLSGWFT
AGYSGGDIY
3D structure
PDB3qgh Investigation of the mode of binding of a novel series of N-benzyl-4-heteroaryl-1-(phenylsulfonyl)piperazine-2-carboxamides to the hepatitis C virus polymerase.
ChainA
Resolution2.14 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.7.7.48: RNA-directed RNA polymerase.
3.4.21.98: hepacivirin.
3.4.22.-
3.6.1.15: nucleoside-triphosphate phosphatase.
3.6.4.13: RNA helicase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 63F A Y191 F193 Y195 S196 P197 R200 S288 C289 C366 S368 M414 F415 I447 Y448 Y452 I454 F551 Y555 Y189 F191 Y193 S194 P195 R198 S286 C287 C364 S366 M412 F413 I445 Y446 Y450 I452 F549 Y553
Gene Ontology
Molecular Function
GO:0003723 RNA binding
GO:0003968 RNA-dependent RNA polymerase activity
Biological Process
GO:0039694 viral RNA genome replication

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Molecular Function
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Biological Process
External links
PDB RCSB:3qgh, PDBe:3qgh, PDBj:3qgh
PDBsum3qgh
PubMed21441029
UniProtP26664|POLG_HCV1 Genome polyprotein

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