Structure of PDB 3qgd Chain A

Receptor sequence
>3qgdA (length=538) Species: 31647 (Hepatitis C virus subtype 1b) [Search protein sequence]
SMSYTWTGALITPCRSASLRQKKVTFDRLQVLDDHYRDVLKEMKAKASTV
KAKLLSVEEACKLTPPHSARSKFGYGAKDVRNLSSKAVNHIRSVWKDLLE
DTETPIDTTIMAKNEVFCVQPEKGGRKPARLIVFPDLGVRVCEKMALYDV
VSTLPQAVMGSSYGFQYSPGQRVEFLVNAWKAKKCPMGFAYDTRCFDSTV
TENDIRVEESIYQCCDLAPEARQAIRSLTERLYIGGPLTNSKGQNCGYRR
CRASGVLTTSCGNTLTCYLKAAAACRAAKLQDCTMLVCGDDLVVICESAG
TQEDEASLRAFTEAMTRYSAPPGDPPKPEYDLELITSCSSNVSVAHDASG
KRVYYLTRDPTTPLARAAWETARHTPVNSWLGNIIMYAPTLWARMILMTH
FFSILLAQEQLEKALDCQIYGACYSIEPLDLPQIIQRLHGLSAFSLHSYS
PGEINRVASCLRKLGVPPLRVWRHRARSVRARLLSQGGRAATCGKYLFNW
AVRTKLKLTPIPAASQLDLSSWFVAGYSGGDIYHSLSR
3D structure
PDB3qgd Investigation of the mode of binding of a novel series of N-benzyl-4-heteroaryl-1-(phenylsulfonyl)piperazine-2-carboxamides to the hepatitis C virus polymerase.
ChainA
Resolution2.6 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.7.7.48: RNA-directed RNA polymerase.
3.4.21.98: hepacivirin.
3.4.22.-
3.6.1.15: nucleoside-triphosphate phosphatase.
3.6.4.13: RNA helicase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 23E A L392 A395 A396 I424 H428 L492 G493 V494 P495 P496 R498 V499 W500 R503 L364 A367 A368 I396 H400 L464 G465 V466 P467 P468 R470 V471 W472 R475
Gene Ontology
Molecular Function
GO:0003723 RNA binding
GO:0003968 RNA-dependent RNA polymerase activity
Biological Process
GO:0039694 viral RNA genome replication

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Molecular Function
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Biological Process
External links
PDB RCSB:3qgd, PDBe:3qgd, PDBj:3qgd
PDBsum3qgd
PubMed21441029
UniProtQ9WMX2|POLG_HCVCO Genome polyprotein

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