Structure of PDB 3qft Chain A

Receptor sequence
>3qftA (length=433) Species: 9606 (Homo sapiens) [Search protein sequence]
RQYELVVHTDIDAAKVYMGEMGRLKSYENQKPPFDAKNPFLAAVTTNRKL
NQGTERHLMHLELDISDSKIRYESGDHVAVYPANDSALVNQLGKILGADL
DVVMSLNNLDEESNKKHPFPCPTSYRTALTYYLDITNPPRTNVLYELAQY
ASEPSEQELLRKMASSSGEGKELYLSWVVEARRHILAILQDCPSLRPPID
HLCELLPRLQAHYYSIASSSKVHPNSVHICAVVVEYETKAGRINKGVATN
WLRAKEPVNGGRALVPMFVRKSQFRLPFKATTPVIMVGPGTGVAPFIGFI
QERAWLRQQGKEVGETLLYYGCRRSDEDYLYREELAQFHRDGALTQLNVA
FSREQSHKVYVQHLLKQDREHLWKLIEGGAHIYVCGDARNMARDVQNTFY
DIVAELGAMEHAQAVDYIKKLMTKGRYSLDVWS
3D structure
PDB3qft Structural basis for human NADPH-cytochrome P450 oxidoreductase deficiency.
ChainA
Resolution1.4 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) P277 Y459 S460 C632 D677 W679
Catalytic site (residue number reindexed from 1) P32 Y214 S215 C385 D430 W432
Enzyme Commision number 1.6.2.4: NADPH--hemoprotein reductase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 FAD A H322 R427 H457 Y458 Y459 S460 C475 A476 Y481 G491 V492 A493 T494 W679 H77 R182 H212 Y213 Y214 S215 C230 A231 Y236 G246 V247 A248 T249 W432
BS02 NAP A R301 G537 T538 C569 R570 S599 R600 K605 Y607 Q609 M638 R56 G290 T291 C322 R323 S352 R353 K358 Y360 Q362 M391
Gene Ontology
Molecular Function
GO:0016491 oxidoreductase activity

View graph for
Molecular Function
External links
PDB RCSB:3qft, PDBe:3qft, PDBj:3qft
PDBsum3qft
PubMed21808038
UniProtP16435|NCPR_HUMAN NADPH--cytochrome P450 reductase (Gene Name=POR)

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