Structure of PDB 3qfs Chain A

Receptor sequence
>3qfsA (length=435) Species: 9606 (Homo sapiens) [Search protein sequence]
RQYELVVHTDIDAAKVYMGEMGRLKSYENQKPPFDAKNPFLAAVTTNRKL
NQGTERHLMHLELDISDSKIRYESGDHVAVYPANDSALVNQLGKILGADL
DVVMSLNNLDEESNKKHPFPCPTSYRTALTYYLDITNPPRTNVLYELAQY
ASEPSEQELLRKMASSSGEGKELYLSWVVEARRHILAILQDCPSLRPPID
HLCELLPRLQARYYSIASSSKVHPNSVHICAVVVEYETKAGRINKGVATN
WLRAKEPVGENGGRALVPMFVRKSQFRLPFKATTPVIMVGPGTGVAPFIG
FIQERAWLRQQGKEVGETLLYYGCRRSDEDYLYREELAQFHRDGALTQLN
VAFSREQSHKVYVQHLLKQDREHLWKLIEGGAHIYVCGDARNMARDVQNT
FYDIVAELGAMEHAQAVDYIKKLMTKGRYSLDVWS
3D structure
PDB3qfs Structural basis for human NADPH-cytochrome P450 oxidoreductase deficiency.
ChainA
Resolution1.4 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) P277 Y459 S460 C632 D677 W679
Catalytic site (residue number reindexed from 1) P32 Y214 S215 C387 D432 W434
Enzyme Commision number 1.6.2.4: NADPH--hemoprotein reductase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 FAD A H322 R427 R457 Y458 Y459 S460 A476 Y481 G491 V492 A493 T494 W679 H77 R182 R212 Y213 Y214 S215 A231 Y236 G246 V247 A248 T249 W434
BS02 NAP A R301 G537 T538 C569 R570 S599 R600 K605 Y607 Q609 M638 R56 G292 T293 C324 R325 S354 R355 K360 Y362 Q364 M393
Gene Ontology
Molecular Function
GO:0016491 oxidoreductase activity

View graph for
Molecular Function
External links
PDB RCSB:3qfs, PDBe:3qfs, PDBj:3qfs
PDBsum3qfs
PubMed21808038
UniProtP16435|NCPR_HUMAN NADPH--cytochrome P450 reductase (Gene Name=POR)

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