Structure of PDB 3qfr Chain A

Receptor sequence

>3qfrA (length=604) Species: 9606 (Homo sapiens) [Search protein sequence]

SSFVEKMKKTGRNIIVFYGSQTGTAEEFANRLSKDAHRYGMRGMSADPEE
YDLADLSSLPEIDNALVVFCMATYGEGDPTDNAQDFYDWLQETDVDLSGV
KFAVFGLGNKTYEHFNAMGKYVDKRLEQLGAQRIFELGLGDDDGNLEEDF
ITWREQFWPAVCEHFGVEATGEESSIRQYELVVHTDIDAAKVYMGEMGRL
KSYENQKPPFDAKNPFLAAVTTNRKLNQGTERHLMHLELDISDSKIRYES
GDHVAVYPANDSALVNQLGKILGADLDVVMSLNNLDEESNKKHPFPCPTS
YRTALTYYLDITNPPRTNVLYELAQYASEPSEQELLRKMASSSGEGKELY
LSWVVEARRHILAILQDCPSLRPPIDHLCELLPRLQAHYYSIASSSKVHP
NSVHICAVVVEYETKAGRINKGVATNWLRAKEPALVPMFVRKSQFRLPFK
ATTPVIMVGPGTGVAPFIGFIQERAWLRQQGKEVGETLLYYGCRRSDEDY
LYREELAQFHRDGALTQLNVAFSREQSHKVYVQHLLKQDREHLWKLIEGG
AHIYVCGDARNMARDVQNTFYDIVAELGAMEHAQAVDYIKKLMTKGRYSL
DVWS

3D structure

PDB

3qfr Structural basis for human NADPH-cytochrome P450 oxidoreductase deficiency.

Chain

Resolution

2.4 Å

3D
structure

Catalytic site residues are labeled in the structure
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Enzymatic activity

Catalytic site (original residue number in PDB)	Y459 S460 C632 D677 W679
Catalytic site (residue number reindexed from 1)	Y390 S391 C556 D601 W603
Enzyme Commision number	1.6.2.4: NADPH--hemoprotein reductase.

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)
BS01	FAD	A	H322 R427 H457 Y458 Y459 S460 A476 V479 Y481 G491 V492 A493 T494 W679	H253 R358 H388 Y389 Y390 S391 A407 V410 Y412 G422 V423 A424 T425 W603
BS02	FMN	A	S89 Q90 T91 T93 A94 T142 Y143 G144 G177 N178 Y181 F184 N185	S20 Q21 T22 T24 A25 T73 Y74 G75 G108 N109 Y112 F115 N116
BS03	NAP	A	R301 P536 G537 T538 C569 R570 S599 R600 K605 Y607 Q609 N637 M638	R232 P460 G461 T462 C493 R494 S523 R524 K529 Y531 Q533 N561 M562

Gene Ontology

	Molecular Function
GO:0003958	NADPH-hemoprotein reductase activity
GO:0005515	protein binding
GO:0010181	FMN binding
GO:0016491	oxidoreductase activity
GO:0050660	flavin adenine dinucleotide binding
GO:0050661	NADP binding

	Biological Process
GO:0006805	xenobiotic metabolic process
GO:0009725	response to hormone
GO:0022900	electron transport chain
GO:0032770	positive regulation of monooxygenase activity
GO:0090346	cellular organofluorine metabolic process

	Cellular Component
GO:0005737	cytoplasm
GO:0005783	endoplasmic reticulum
GO:0005789	endoplasmic reticulum membrane
GO:0005829	cytosol
GO:0016020	membrane
GO:0043231	intracellular membrane-bounded organelle

View graph for
Molecular Function

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Biological Process

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Cellular Component

External links

PDB	RCSB:3qfr, PDBe:3qfr, PDBj:3qfr
PDBsum	3qfr
PubMed	21808038
UniProt	P16435\|NCPR_HUMAN NADPH--cytochrome P450 reductase (Gene Name=POR)

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