Structure of PDB 3qfc Chain A

Receptor sequence

>3qfcA (length=607) Species: 9606 (Homo sapiens) [Search protein sequence]

ESSFVEKMKKTGRNIIVFYGSQTGTAEEFANRLSKDAHRYGMRGMSADPE
EYDLADLSSLPEIDNALVVFCMATYGEGDPTDNAQDFYDWLQETDVDLSG
VKFAVFGLGNKTYEHFNAMGKYVDKRLEQLGAQRIFELGLGDDDGNLEED
FITWREQFWLAVCEHFGVEATGEESSIRQYELVVHTDIDAAKVYMGEMGR
LKSYENQKPPFDAKNPFLAAVTTNRKLNQGTERHLMHLELDISDSKIRYE
SGDHVAVYPANDSALVNQLGKILGADLDVVMSLNNLDEESNKKHPFPCPT
SYRTALTYYLDITNPPRTNVLYELAQYASEPSEQELLRKMASSSGEGKEL
YLSWVVEARRHILAILQDCPSLRPPIDHLCELLPRLQARYYSIASSSKVH
PNSVHICAVVVEYETKAGRINKGEATNWLRAKEPVRALVPMFVRKSQFRL
PFKATTPVIMVGPGTGVAPFIGFIQERAWLRQQGKEVGETLLYYGCRRSD
EDYLYREELAQFHRDGALTQLNVAFSREQSHKVYVQHLLKQDREHLWKLI
EGGAHIYVCGDARNMARDVQNTFYDIVAELGAMEHAQAVDYIKKLMTKGR
YSLDVWS

3D structure

PDB

3qfc Structural basis for human NADPH-cytochrome P450 oxidoreductase deficiency.

Chain

Resolution

1.8 Å

3D
structure

Catalytic site residues are labeled in the structure
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Enzymatic activity

Catalytic site (original residue number in PDB)	Y459 S460 C632 D677 W679
Catalytic site (residue number reindexed from 1)	Y391 S392 C559 D604 W606
Enzyme Commision number	1.6.2.4: NADPH--hemoprotein reductase.

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)
BS01	FAD	A	H322 R427 R457 Y458 Y459 S460 C475 A476 Y481 G491 E492 A493 T494 W679	H254 R359 R389 Y390 Y391 S392 C407 A408 Y413 G423 E424 A425 T426 W606
BS02	FMN	A	S89 Q90 T91 T93 A94 A141 T142 Y143 L176 G177 N178 Y181 H183 F184	S21 Q22 T23 T25 A26 A73 T74 Y75 L108 G109 N110 Y113 H115 F116
BS03	NAP	A	R301 G537 T538 C569 R570 S599 R600 K605 Y607 Q609 N637 M638	R233 G464 T465 C496 R497 S526 R527 K532 Y534 Q536 N564 M565

Gene Ontology

	Molecular Function
GO:0003958	NADPH-hemoprotein reductase activity
GO:0005515	protein binding
GO:0010181	FMN binding
GO:0016491	oxidoreductase activity
GO:0050660	flavin adenine dinucleotide binding
GO:0050661	NADP binding

	Biological Process
GO:0006805	xenobiotic metabolic process
GO:0009725	response to hormone
GO:0022900	electron transport chain
GO:0032770	positive regulation of monooxygenase activity
GO:0090346	cellular organofluorine metabolic process

	Cellular Component
GO:0005737	cytoplasm
GO:0005783	endoplasmic reticulum
GO:0005789	endoplasmic reticulum membrane
GO:0005829	cytosol
GO:0016020	membrane
GO:0043231	intracellular membrane-bounded organelle

View graph for
Molecular Function

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Biological Process

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Cellular Component

External links

PDB	RCSB:3qfc, PDBe:3qfc, PDBj:3qfc
PDBsum	3qfc
PubMed	21808038
UniProt	P16435\|NCPR_HUMAN NADPH--cytochrome P450 reductase (Gene Name=POR)

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