Structure of PDB 3qe3 Chain A

Receptor sequence
>3qe3A (length=351) Species: 9940 (Ovis aries) [Search protein sequence]
AENLSLVVHGPGDLRLENYPIPEPGPNEVLLKMHSVGICGSDVHYWQHGR
IGDFVVKKPMVLGHEASGTVVKVGSLVRHLQPGDRVAIQPGAPRQTDEFC
KIGRYNLSPTIFFCATPPDDGNLCRFYKHNANFCYKLPDNVTFEEGALIE
PLSVGIHACRRAGVTLGNKVLVCGAGPIGLVNLLAAKAMGAAQVVVTDLS
ASRLSKAKEVGADFILEISNESPEEIAKKVEGLLGSKPEVTIECTGVETS
IQAGIYATHSGGTLVLVGLGSEMTSVPLVHAATREVDIKGVFRYCNTWPM
AISMLASKSVNVKPLVTHRFPLEKALEAFETSKKGLGLKVMIKCDPSDQN
P
3D structure
PDB3qe3 X-ray crystal structure and small-angle X-ray scattering of sheep liver sorbitol dehydrogenase.
ChainA
Resolution1.9 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) C43 G44 S45 H48 H68 E69 R98 D101 C104 S112 F116 P155 G159 K343
Catalytic site (residue number reindexed from 1) C39 G40 S41 H44 H64 E65 R94 D97 C100 S108 F112 P151 G155 K339
Enzyme Commision number 1.1.1.-
1.1.1.14: L-iditol 2-dehydrogenase.
1.1.1.9: D-xylulose reductase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ZN A C43 H68 E69 C39 H64 E65
BS02 GOL A Y49 F58 T120 R297 Y45 F54 T116 R293
Gene Ontology
Molecular Function
GO:0008270 zinc ion binding
GO:0016491 oxidoreductase activity
GO:0016616 oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor

View graph for
Molecular Function
External links
PDB RCSB:3qe3, PDBe:3qe3, PDBj:3qe3
PDBsum3qe3
PubMed21543846
UniProtP07846|DHSO_SHEEP Sorbitol dehydrogenase (Gene Name=SORD)

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