Structure of PDB 3qbt Chain A

Receptor sequence
>3qbtA (length=170) Species: 9606 (Homo sapiens) [Search protein sequence]
YLFKLLLIGDSGVGKTCVLFRFSEDAFNSTFISTIGIDFKIRTIELDGKR
IKLQIWDTAGQERFRTITTAYYRGAMGIMLVYDITNEKSFDNIRNWIRNI
EEHASADVEKMILGNKCDVNDKRQVSKERGEKLALDYGIKFMETSAKANI
NVENAFFTLARDIKAKMDKK
3D structure
PDB3qbt A structural basis for Lowe syndrome caused by mutations in the Rab-binding domain of OCRL1.
ChainA
Resolution2.0 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) Q67
Catalytic site (residue number reindexed from 1) Q61
Enzyme Commision number 3.6.5.2: small monomeric GTPase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 MG A T22 T40 T16 T34
BS02 GNP A S17 G18 V19 G20 K21 T22 C23 F33 S39 T40 G66 K122 D124 S151 K153 S11 G12 V13 G14 K15 T16 C17 F27 S33 T34 G60 K116 D118 S145 K147
Gene Ontology
Molecular Function
GO:0003924 GTPase activity
GO:0005525 GTP binding

View graph for
Molecular Function
External links
PDB RCSB:3qbt, PDBe:3qbt, PDBj:3qbt
PDBsum3qbt
PubMed21378754
UniProtP61006|RAB8A_HUMAN Ras-related protein Rab-8A (Gene Name=RAB8A)

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