Structure of PDB 3qak Chain A

Receptor sequence
>3qakA (length=444) Species: 9606,10665 [Search protein sequence]
IMGSSVYITVELAIAVLAILGNVLVCWAVWLNSNLQNVTNYFVVSLAAAD
IAVGVLAIPFAITISTGFCAACHGCLFIACFVLVLTQSSIFSLLAIAIDR
YIAIRIPLRYNGLVTGTRAKGIIAICWVLSFAIGLTPMLGWNNCGQGCGE
GQVACLFEDVVPMNYMVYFNFFACVLVPLLLMLGVYLRIFLAARRQLNIF
EMLRIDEGLRLKIYKDTEGYYTIGIGHLLTKSPSLNAAKSELDKAIGRNT
NGVITKDEAEKLFNQDVDAAVRGILRNAKLKPVYDSLDAVRRAALINMVF
QMGETGVAGFTNSLRMLQQKRWDEAAVNLAKSRWYNQTPNRAKRVITTFR
TGTWDAYRSTLQKEVHAAKSLAIIVGLFALCWLPLHIINCFTFFCPDCSH
APLWLMYLAIVLSHTNSVVNPFIYAYRIREFRQTFRKIIRSHVL
3D structure
PDB3qak Structure of an agonist-bound human A2A adenosine receptor.
ChainA
Resolution2.71 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) E1011 D1020
Catalytic site (residue number reindexed from 1) E207 D216
Enzyme Commision number 3.2.1.17: lysozyme.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 UKA A T88 F168 E169 M177 W246 N253 T256 H264 L267 M270 Y271 I274 S277 H278 T86 F157 E158 M166 W382 N389 T392 H400 L403 M406 Y407 I410 S413 H414 PDBbind-CN: -logKd/Ki=8.32,Ki=4.75nM
Gene Ontology
Molecular Function
GO:0003796 lysozyme activity
GO:0004930 G protein-coupled receptor activity
GO:0016798 hydrolase activity, acting on glycosyl bonds
Biological Process
GO:0007186 G protein-coupled receptor signaling pathway
GO:0009253 peptidoglycan catabolic process
GO:0016998 cell wall macromolecule catabolic process
GO:0031640 killing of cells of another organism
GO:0042742 defense response to bacterium
GO:0044659 viral release from host cell by cytolysis
Cellular Component
GO:0016020 membrane
GO:0030430 host cell cytoplasm

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Cellular Component
External links
PDB RCSB:3qak, PDBe:3qak, PDBj:3qak
PDBsum3qak
PubMed21393508
UniProtP00720|ENLYS_BPT4 Endolysin (Gene Name=E);
P29274|AA2AR_HUMAN Adenosine receptor A2a (Gene Name=ADORA2A)

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