Structure of PDB 3q8l Chain A

Receptor sequence
>3q8lA (length=341) Species: 9606 (Homo sapiens) [Search protein sequence]
GIQGLAKLIADVAPSAIRENDIKSYFGRKVAIDASMSIYQFLIAVRQGGD
VLQNEEGETTSHLMGMFYRTIRMMENGIKPVYVFDGKPPQLKSGELAKRS
ERRAEAEKQLQQAQAAGAEQEVEKFTKRLVKVTKQHNDECKHLLSLMGIP
YLDAPSEAEASCAALVKAGKVYAAATEDMDCLTFGSPVLMRHLTASEAKK
LPIQEFHLSRILQELGLNQEQFVDLCILLGSDYCESIRGIGPKRAVDLIQ
KHKSIEEIVRRLDPNKYPVPENWLHKEAHQLFLEPEVLDPESVELKWSEP
NEEELIKFMCGEKQFSEERIRSGVKRLSKSRQGSTLEVLFQ
3D structure
PDB3q8l Human Flap Endonuclease Structures, DNA Double-Base Flipping, and a Unified Understanding of the FEN1 Superfamily.
ChainA
Resolution2.319 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.1.-.-
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 dna A Q41 I44 A45 V46 M65 Y69 R70 R73 K201 R239 G240 G242 P243 K244 R245 Q40 I43 A44 V45 M64 Y68 R69 R72 K200 R238 G239 G241 P242 K243 R244
BS02 dna A Y40 R100 E178 M180 K267 Y39 R99 E177 M179 K266
BS03 dna A Q48 L53 Q54 T61 K314 Q315 F316 S317 Q47 L52 Q53 T60 K313 Q314 F315 S316
Gene Ontology
Molecular Function
GO:0003677 DNA binding
GO:0003824 catalytic activity
GO:0004518 nuclease activity
GO:0016788 hydrolase activity, acting on ester bonds

View graph for
Molecular Function
External links
PDB RCSB:3q8l, PDBe:3q8l, PDBj:3q8l
PDBsum3q8l
PubMed21496641
UniProtP39748|FEN1_HUMAN Flap endonuclease 1 (Gene Name=FEN1)

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