Structure of PDB 3q8e Chain A

Receptor sequence
>3q8eA (length=688) Species: 1392 (Bacillus anthracis) [Search protein sequence]
SSQGLLGYYFSDLNFQAPMVVTSSTTGDLSIPSSELENIPSENQYFQSAI
WSGFIKVKKSDEYTFATSADNHVTMWVDDQEVINSNKIRLEKGRLYQIKI
QYQRENPTEKGLDFKLYWTDSQNKKEVISSDNLQLPELKQKSSNSRKKRV
PDRDNDGIPDSLEVEGYTVDVKNKRTFLSPWISNIHEKKGLTKYKSSPEK
WSTASDPYSDFEKVTGRIDKNVSPEARHPLVAAYPIVHVDMENIILSKNE
DQSTQNTDSQTRTISKNTSTSRTHTSSAGFSNSNSSTVAIDHSLSGERTF
AETMGLNTADTARLNANIRYVNTGTAPIYNVLPTTSLVLGKNQTLATIKA
KENQLSQILAPNNYYPSKNLAPIALNAQDDFSSTPITMNYNQFLELEKTK
QLRLDTDQVYGNIATYNFENGRVRVDTGSNWSEVLPQIQETTARIIFNGK
DLNLVERRIAAVNPSDPLETTKPDMTLKEALKIAFGFNEPNGNLQYQGKD
ITEFDFNFDQQTSQNIKNQLAELNATNIYTVLDKIKLNAKMNILIRDKRF
HYDRNNIAVGADESVVKEAHREVINSSTEGLLLNIDKDIRKILSGYIVEI
EDTEGLKEVINDRYDMLNISSLRQDGKTFIDFKKYNDKLPLYISNPNYKV
NVYAVTKENTIINPSENGDTSTNGIKKILIFSKKGYEI
3D structure
PDB3q8e pH effects on binding between the anthrax protective antigen and the host cellular receptor CMG2.
ChainA
Resolution2.098 Å
3D
structure
[Spin on]
[Spin off]
[Reset orientation]

[High quality]
[Low quality]

[White background]
[Black background]

[Download]
[Download structure with residue number starting from 1]
Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 CA A D179 D181 E188 S222 K225 D235 D154 D156 E163 S197 K200 D210
BS02 CA A D177 D179 D181 I183 E188 D152 D154 D156 I158 E163
Gene Ontology
Molecular Function
GO:0005515 protein binding
GO:0042802 identical protein binding
GO:0046872 metal ion binding
GO:0090729 toxin activity
Biological Process
GO:0043409 negative regulation of MAPK cascade
GO:0044533 positive regulation of apoptotic process in another organism
GO:0051260 protein homooligomerization
Cellular Component
GO:0005576 extracellular region
GO:0016020 membrane
GO:0020002 host cell plasma membrane
GO:0044164 host cell cytosol
GO:0044174 host cell endosome
GO:0044175 host cell endosome membrane

View graph for
Molecular Function
View graph for
Biological Process
View graph for
Cellular Component
External links
PDB RCSB:3q8e, PDBe:3q8e, PDBj:3q8e
PDBsum3q8e
PubMed22855243
UniProtP13423|PAG_BACAN Protective antigen (Gene Name=pagA)

[Back to BioLiP]