Structure of PDB 3q8c Chain A

Receptor sequence
>3q8cA (length=675) Species: 1392 (Bacillus anthracis) [Search protein sequence]
SSQGLLGYYFSDLNFQAPMVVTSSTTGDLSIPSSELENIPSENQYFQSAI
WSGFIKVKKSDEYTFATSADNHVTMWVDDQEVINSNKIRLEKGRLYQIKI
QYQRENPTEKGLDFKLYWTDSQNKKEVISSDNLQLPELKQKSSNSRKKRV
PDRDNDGIPDSLEVEGYTVDVKNKRTFLSPWISNIHEKKGLTKYKSSPEK
WSTASDPYSDFEKVTGRIDKNVSPEARHPLVAAYPIVHVDMENIILSKNE
DQSNTDSQTRTISKNTSTSRTHTSSAGFSNSNSSTVAIDHSLLNTADTAR
LNANIRYVNTGTAPIYNVLPTTSLVLGKNQTLATIKAKENQLSQILAPNN
YYPSKNLAPIALNAQDDFSSTPITMNYNQFLELEKTKQLRLDTDQVYGNI
ATYNFENGRVRVDTGSNWSEVLPQIQETTARIIFNGKDLNLVERRIAAVN
PSDPLETTKPDMTLKEALKIAFGFNEPNGNLQYQGKDITEFDFNFDQQTS
QNIKNQLAELNATNIYTVLDKIKLNAKMNILIRDKRFHYDRNNIAVGADE
SVVKEAHREVINSSTEGLLLNIDKDIRKILSGYIVEIEDTEGLKEVINDR
YDMLNISSLRQDGKTFIDFKKYNDKLPLYISNPNYKVNVYAVTKENTIIN
PSENGDTSTNGIKKILIFSKKGYEI
3D structure
PDB3q8c pH effects on binding between the anthrax protective antigen and the host cellular receptor CMG2.
ChainA
Resolution2.85 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 CA A D179 D181 E188 S222 K225 D235 D154 D156 E163 S197 K200 D210
BS02 CA A D177 D179 D181 I183 E188 P223 D152 D154 D156 I158 E163 P198
Gene Ontology
Molecular Function
GO:0005515 protein binding
GO:0042802 identical protein binding
GO:0046872 metal ion binding
GO:0090729 toxin activity
Biological Process
GO:0043409 negative regulation of MAPK cascade
GO:0044533 positive regulation of apoptotic process in another organism
GO:0051260 protein homooligomerization
Cellular Component
GO:0005576 extracellular region
GO:0016020 membrane
GO:0020002 host cell plasma membrane
GO:0044164 host cell cytosol
GO:0044174 host cell endosome
GO:0044175 host cell endosome membrane

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:3q8c, PDBe:3q8c, PDBj:3q8c
PDBsum3q8c
PubMed22855243
UniProtP13423|PAG_BACAN Protective antigen (Gene Name=pagA)

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