Structure of PDB 3q8a Chain A

Receptor sequence
>3q8aA (length=673) Species: 1392 (Bacillus anthracis) [Search protein sequence]
SSQGLLGYYFSDLNFQAPMVVTSSTTGDLSIPSSELSENQYFQSAIWSGF
IKVSDEYTFATSADNHVTMWVDDQEVINNKIRLEKGRLYQIKIQYQRENP
TEKGLDFKLYWTDSQNKKEVISSDNLQLPELKQKSSNSRKKRPDRDNDGI
PDSLEVEGYTVDVKNKRTFLSPWISNIHEKKGLTKYKSSPEKWSTASDPY
SDFEKVTGRIDKNVSPEARHPLVAAYPIVHVDMENIILSKNEDSQTRTIS
KNTSTSRTHTSAGFSNSNSSTVAIDHSLSAGERTWAETMGLNTADTARLN
ANIRYVNTGTAPIYNVLPTTSLVLGKNQTLATIKAKENQLSQILAPNNYY
PSKNLAPIALNAQDDFSSTPITMNYNQFLELEKTKQLRLDTDQVYGNIAT
YNFENGRVRVDTGSNWSEVLPQIQETTARIIFNGKDLNLVERRIAAVNPS
DPLETTKPDMTLKEALKIAFGFNEPNGNLQYQGKDITEFDFNFDQQTSQN
IKNQLAELNATNIYTVLDKIKLNAKMNILIRDKRFHYDRNNIAVGADESV
VKEAHREVINSSTEGLLLNIDKDIRKILSGYIVEIEDTEGLKEVINDRYD
MLNISSLRQDGKTFIDFKKYNDKLPLYISNPNYKVNVYAVTKENTIINPS
ENGDTSTNGIKKILIFSKKGYEI
3D structure
PDB3q8a pH effects on binding between the anthrax protective antigen and the host cellular receptor CMG2.
ChainA
Resolution3.129 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 CA A D179 D181 E188 S221 S222 P223 D235 D146 D148 E155 S188 S189 P190 D202
BS02 CA A D177 D179 D181 I183 E188 D144 D146 D148 I150 E155
Gene Ontology
Molecular Function
GO:0005515 protein binding
GO:0042802 identical protein binding
GO:0046872 metal ion binding
GO:0090729 toxin activity
Biological Process
GO:0043409 negative regulation of MAPK cascade
GO:0044533 positive regulation of apoptotic process in another organism
GO:0051260 protein homooligomerization
Cellular Component
GO:0005576 extracellular region
GO:0016020 membrane
GO:0020002 host cell plasma membrane
GO:0044164 host cell cytosol
GO:0044174 host cell endosome
GO:0044175 host cell endosome membrane

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:3q8a, PDBe:3q8a, PDBj:3q8a
PDBsum3q8a
PubMed22855243
UniProtP13423|PAG_BACAN Protective antigen (Gene Name=pagA)

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