Structure of PDB 3q88 Chain A

Receptor sequence

>3q88A (length=541) Species: 177416 (Francisella tularensis subsp. tularensis SCHU S4)

NAMLFCDDSKKYLKEQNINLKNEFDKDDKRVEKFSLKHQNIYFDYSKNLI
NDYILKSLLESAEKSSLKDKIKQMFNGAKINSTEHRAVLHTALRDLSSTP
LIVDGQDIRQEVTKEKQRVKELVEKVVSGRWRGFSGKKITDIVNIGIGGS
DLGPKMVVRALQPYHCTDLKVHFVSNVDADSLLQALHVVDPETTLLIIAS
KSFSTEETLLNSISAREWLLDHYEDEKAVANHFVAISSKLDKVKEFGIDL
EHCYKMWDWVGGRYSLWSSIGMSIAFAIGYDNFEKLLAGAYSVDKHFKET
EFSKNIPVIMALLASYYSCTYNSQSQALLPYDERLCYFVDYLQQADMESN
GKSVNIAGETVNYQTGVVLWGGVGTNGQHAFHQLLHQGNIFIPVDFIAIA
TSHHNYDNHQQALLANCFAQSQALMFGQSYDMVYNELLKSGLNETQAKEL
AAHKVIPGNRPSTTILLDELSPYSLGALIALYEHKIFVQGVLWDINSYDQ
WGVELGKKLGKNILKAMNDDSSDEYQNLDDSTRQLIAKVKN

3D structure

• PDB: 3q88 Glucose-6-phosphate isomerase from Francisella tularensis.
• Chain: A
• Resolution: 1.7 Å

Enzymatic activity

• Catalytic site (original residue number in PDB): K199 E205 G260 R261 E346 H377 K505
• Catalytic site (residue number reindexed from 1): K201 E207 G262 R263 E348 H379 K507
• Enzyme Commision number: 5.3.1.9: glucose-6-phosphate isomerase.

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	RI2	A	I145 G146 G147 S148 S198 K199 S200 T203 E346 V501 K505	I147 G148 G149 S150 S200 K201 S202 T205 E348 V503 K507

Gene Ontology

Molecular Function

• GO:0004347 glucose-6-phosphate isomerase activity
• GO:0016853 isomerase activity
• GO:0048029 monosaccharide binding
• GO:0097367 carbohydrate derivative binding

Biological Process

• GO:0006094 gluconeogenesis
• GO:0006096 glycolytic process
• GO:0051156 glucose 6-phosphate metabolic process
• GO:1901135 carbohydrate derivative metabolic process

Cellular Component

• GO:0005737 cytoplasm
• GO:0005829 cytosol

External links

• PDB: RCSB:3q88, PDBe:3q88, PDBj:3q88
• PDBsum: 3q88
• UniProt: Q5NFC4|G6PI_FRATT Glucose-6-phosphate isomerase (Gene Name=pgi)