Structure of PDB 3q70 Chain A

Receptor sequence
>3q70A (length=334) Species: 5476 (Candida albicans) [Search protein sequence]
QAVPVTLHNEQVTYAADITVGSNNQKLNVIVDTGSSDLWVPDVNVDCQVT
YSDQTADFCKQKGTYDPSGSSASQDLNTPFKIGYGDGSSSQGTLYKDTVG
FGGVSIKNQVLADVDSTSIDQGILGVGYKTNEAGGSYDNVPVTLKKQGVI
AKNAYSLYLNSPDAATGQIIFGGVDNAKYSGSLIALPVTSDRELRISLGS
VEVSGKTINTDNVDVLLDSGTTITYLQQDLADQIIKAFNGKLTQDSNGNS
FYEVDCNLSGDVVFNFSKNAKISVPASEFAASLDKCQLLFDVNDANILGD
NFLRSAYIVYDLDDNEISLAQVKYTSASSISALT
3D structure
PDB3q70 The bindingmode of HIV-1 protease inhibitors to pepsin-like aspartic proteinases
ChainA
Resolution1.4 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) D32 S35 D37 W39 Y84 D218 T221
Catalytic site (residue number reindexed from 1) D32 S35 D37 W39 Y84 D218 T221
Enzyme Commision number 3.4.23.24: candidapepsin.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 RIT A D32 G34 G83 Y84 G85 I119 N131 D218 G220 T221 T222 Y225 D32 G34 G83 Y84 G85 I119 N131 D218 G220 T221 T222 Y225
Gene Ontology
Molecular Function
GO:0004190 aspartic-type endopeptidase activity
GO:0046872 metal ion binding
Biological Process
GO:0006508 proteolysis
Cellular Component
GO:0005576 extracellular region

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:3q70, PDBe:3q70, PDBj:3q70
PDBsum3q70
PubMed
UniProtP0CS83|CARP2_CANAX Secreted aspartic protease 2 (Gene Name=SAP2)

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